Grb-2: Difference between revisions
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Grb-2 stands for growth factor receptor bound protein 2 <ref name="Wikipedia">growth factor receptor protein</ref>, is an adaptor protein found in humans. This adaptor [[ | Grb-2 stands for growth factor receptor bound protein 2 <ref name="Wikipedia">growth factor receptor protein</ref>, is an [[adaptor protein|adaptor protein]] found in humans. This adaptor [[Protein|protein]] is also present in the [[Ras signalling Pathway|Ras signalling pathway]]. What it does is that it bind to the receptor tyrosine kinase (Grb2 has an [[SH2 domains|SH2 domain]]), which then binds the [[GEF|GEF]], which causes the release of [[GDP|GDP]] by [[Ras|Ras]] ([[Ras|Ras]] is a [[Monomeric G-protein|monomeric G-protein]]), which then takes up [[GTP|GTP]], causing activation, which in turn delivers the signal on to other [[Kinase|kinases]].<br> | ||
=== References === | === References === | ||
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Latest revision as of 12:20, 17 November 2011
Grb-2 stands for growth factor receptor bound protein 2 [1], is an adaptor protein found in humans. This adaptor protein is also present in the Ras signalling pathway. What it does is that it bind to the receptor tyrosine kinase (Grb2 has an SH2 domain), which then binds the GEF, which causes the release of GDP by Ras (Ras is a monomeric G-protein), which then takes up GTP, causing activation, which in turn delivers the signal on to other kinases.
References
- ↑ growth factor receptor protein