Abnormal Processing: Difference between revisions
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Class II mutations for [[ | Class II mutations for [[Cystic fibrosis|Cystic Fibrosis]] are caused by a mutation which causes abnormal folding of the [[Proteins|protein]]. These are recognised by a 'quality control' mechanism which causes the abnormal [[Proteins|protein]] to be digested by [[Proteasome|proteasomes]]. As a result the [[CFTR|CFTR]] [[Proteins|protein]] doesn't reach the cell membrane resulting in [[Cystic fibrosis|Cystic Fibrosis]]. | ||
Latest revision as of 06:12, 28 November 2011
Class II mutations for Cystic Fibrosis are caused by a mutation which causes abnormal folding of the protein. These are recognised by a 'quality control' mechanism which causes the abnormal protein to be digested by proteasomes. As a result the CFTR protein doesn't reach the cell membrane resulting in Cystic Fibrosis.