Pharmacotherapy of Cystic Fibrosis: Difference between revisions
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== Pharmacotherapy of Cystic Fibrosis == | == Pharmacotherapy of Cystic Fibrosis == | ||
Pharmacotherapy relates to the use of chemical drugs to regulate and improve the function of defective [[ | Pharmacotherapy relates to the use of chemical drugs to regulate and improve the function of defective [[Cystic fibrosis|CFTR]] channels.<br> | ||
===== Potentiators ===== | |||
Example VX-770 | |||
Attempt to correct Class III and Class IV [[CFTR|CFTR]] mutations by increasing the conductance of the [[CFTR|CFTR]] channel. | |||
===== Correctors ===== | |||
Example Trimethyl-oxide | |||
Attempt to correct Class II [[CFTR|CFTR]] mutations by improving the trafficking of [[CFTR|CFTR]] channels to the [[Lipid bi-layer|Cell Membrane]]. | |||
Attempt to correct Class II CFTR mutations by improving the trafficking of CFTR channels to the [[Lipid bi-layer|Cell Membrane]]. | |||
Revision as of 17:03, 8 November 2010
Pharmacotherapy of Cystic Fibrosis
Pharmacotherapy relates to the use of chemical drugs to regulate and improve the function of defective CFTR channels.
Potentiators
Example VX-770
Attempt to correct Class III and Class IV CFTR mutations by increasing the conductance of the CFTR channel.
Correctors
Example Trimethyl-oxide
Attempt to correct Class II CFTR mutations by improving the trafficking of CFTR channels to the Cell Membrane.