SH2 domains: Difference between revisions
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SH2 ('''S'''rc '''H'''omology '''2''') domains are phosphotyrosine residue binding domains which are heavily involved in signalling and cell communication. It has a number of important roles such as | SH2 ('''S'''rc '''H'''omology '''2''') domains are [[phosphotyrosine|phosphotyrosine]] residue binding domains which are heavily involved in signalling and cell communication. It has a number of important roles such as stabilising the inactive state of members of the [[Src family|Src family]] but it is also required by [[Non-receptor tyrosine kinases|non-receptor tyrosine kinases]] in order to stabalize their active state <ref name="SH2 overview">P.Filippakopoulos, S.Muller, S.Knapp. SH2 domains: modulators of nonreceptor tyrosine kinase activity. Curr Opin Struct Biol. 2009 December; 19(6): 643–649.</ref>. | ||
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Latest revision as of 17:58, 18 October 2012
SH2 (Src Homology 2) domains are phosphotyrosine residue binding domains which are heavily involved in signalling and cell communication. It has a number of important roles such as stabilising the inactive state of members of the Src family but it is also required by non-receptor tyrosine kinases in order to stabalize their active state [1].
References
- ↑ P.Filippakopoulos, S.Muller, S.Knapp. SH2 domains: modulators of nonreceptor tyrosine kinase activity. Curr Opin Struct Biol. 2009 December; 19(6): 643–649.