Antagonist: Difference between revisions
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A [[Compound|compound]] (usually [[Synthetic|synthetic]]) that inhibits the action of its natural counterpart by binding to a [[Receptor|receptor]] or [[Protein|protein]]. | A [[Compound|compound]] (usually [[Synthetic|synthetic]]) that inhibits the action of its natural counterpart by binding to a [[Receptor|receptor]] or [[Protein|protein]]. There are three classes of antagonist, chemical, physiological and pharmacological. | ||
A pharmacalogical example is [[Tamoxifen|Tamoxifen]], a drug which acts on estrogen receptor. Also see [[Agonist|agonist]]. | Pharmacological antagonists can be further characterised as: | ||
* Competetive which binds to the binding site of a receptor and can be overcome by increasing the concentration of an agonist (competitor). | |||
*Irreversible competitive which forms a covalent bond with the receptor. | |||
*Non-competetive antagonists whichblocks the signal transduction event of the receptor. | |||
A pharmacalogical example of an antagonist is [[Tamoxifen|Tamoxifen]], a drug which acts on estrogen receptor. Also see [[Agonist|agonist]]. | |||
Revision as of 14:17, 20 October 2012
A compound (usually synthetic) that inhibits the action of its natural counterpart by binding to a receptor or protein. There are three classes of antagonist, chemical, physiological and pharmacological.
Pharmacological antagonists can be further characterised as:
- Competetive which binds to the binding site of a receptor and can be overcome by increasing the concentration of an agonist (competitor).
- Irreversible competitive which forms a covalent bond with the receptor.
- Non-competetive antagonists whichblocks the signal transduction event of the receptor.
A pharmacalogical example of an antagonist is Tamoxifen, a drug which acts on estrogen receptor. Also see agonist.