Antagonist

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A compound (usually synthetic) that inhibits the action of its natural counterpart by binding to a receptor or protein. There are three classes of antagonist, chemical, physiological and pharmacological.

Pharmacological antagonists can be further characterised as:

A pharmacalogical example of an antagonist is Tamoxifen, a drug which acts on estrogen receptor and is often used in the treatment of breast cancer.

Chemical antagonism occurs when the drug in question causes an effect by preventing the formation of a chemical compound.

See also agonist.

References

  1. Rang, H. and Dale, M. (2012). Rang and Dale's pharmacology. Edinburgh: Elsevier/Churchill Livingstone pg160
  2. Golan D. Principles of Pharmacology [Internet]. Google Books. 2016 [cited 20 October 2016]. Available from: https://books.google.com.my/books?id=az8uSDkB0mgC&pg=PA23&lpg=PA23&dq=noncompetitive+active+site+antagonist&redir_esc=y&hl=en#v=onepage&q&f=false
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