Mitogen-Activated Protein Kinase: Difference between revisions

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'''&nbsp;Mitogen-Activated Protein Kinases (MAPKs)''' are a family of kinases with vital roles among eukaryotes in the following cellular processes: proliferation, differentiation, movement, response to environmental changes, and death<ref name="Junttila MR Et. Al. (2008)" />. &nbsp;MAPKs phosphorylate and are phosphorylated on serine/threonine residues. &nbsp;These kinases have been observed to function in cascades starting with Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK) which phosphorylates Mitogen-Activated Protein Kinase Kinase (MAPKK) which finally phosphorylates a MAPK<ref />. &nbsp;The MAPK may either directly elicite a cellular action or phosphorylate an effector protein that will elicite a cellular response<ref />. &nbsp;
'''Mitogen-Activated Protein Kinases (MAPKs)''' are a family of [[Kinase|kinases]] with vital roles among [[Eukaryotes|eukaryotes]] in the following cellular processes: proliferation, differentiation, movement, response to environmental changes, and death <ref>Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.</ref>. &nbsp;MAPKs [[Phosphorylation|phosphorylate]] and are phosphorylated on [[Serine|serine]]/[[Threonine|threonine]] residues. &nbsp;These kinases have been observed to function in cascades starting with [[Mitogen-Activated Protein Kinase Kinase Kinase|Mitogen-Activated Protein Kinase Kinase Kinase]] (MAPKKK) which phosphorylates [[Mitogen-Activated Protein Kinase Kinase|Mitogen-Activated Protein Kinase Kinase]] (MAPKK) which finally phosphorylates a MAPK <ref>Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.</ref>. &nbsp;The MAPK may either directly elicite a cellular action or phosphorylate an effector protein that will elicite a cellular response&nbsp;<ref>Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.</ref>. &nbsp;  
 
=== References<br> ===
 
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<references />Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.

Latest revision as of 15:48, 22 October 2012

Mitogen-Activated Protein Kinases (MAPKs) are a family of kinases with vital roles among eukaryotes in the following cellular processes: proliferation, differentiation, movement, response to environmental changes, and death [1].  MAPKs phosphorylate and are phosphorylated on serine/threonine residues.  These kinases have been observed to function in cascades starting with Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK) which phosphorylates Mitogen-Activated Protein Kinase Kinase (MAPKK) which finally phosphorylates a MAPK [2].  The MAPK may either directly elicite a cellular action or phosphorylate an effector protein that will elicite a cellular response [3].  

References

  1. ↑ Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.
  2. ↑ Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.
  3. ↑ Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.


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