Mitogen-Activated Protein Kinase: Difference between revisions
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'''Mitogen-Activated Protein Kinases (MAPKs)''' are a family of [[ | '''Mitogen-Activated Protein Kinases (MAPKs)''' are a family of [[Kinase|kinases]] with vital roles among [[Eukaryotes|eukaryotes]] in the following cellular processes: proliferation, differentiation, movement, response to environmental changes, and death <ref>Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.</ref>. MAPKs [[Phosphorylation|phosphorylate]] and are phosphorylated on [[Serine|serine]]/[[Threonine|threonine]] residues. These kinases have been observed to function in cascades starting with [[Mitogen-Activated Protein Kinase Kinase Kinase|Mitogen-Activated Protein Kinase Kinase Kinase]] (MAPKKK) which phosphorylates [[Mitogen-Activated Protein Kinase Kinase|Mitogen-Activated Protein Kinase Kinase]] (MAPKK) which finally phosphorylates a MAPK <ref>Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.</ref>. The MAPK may either directly elicite a cellular action or phosphorylate an effector protein that will elicite a cellular response <ref>Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.</ref>. | ||
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Latest revision as of 15:48, 22 October 2012
Mitogen-Activated Protein Kinases (MAPKs) are a family of kinases with vital roles among eukaryotes in the following cellular processes: proliferation, differentiation, movement, response to environmental changes, and death [1]. MAPKs phosphorylate and are phosphorylated on serine/threonine residues. These kinases have been observed to function in cascades starting with Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK) which phosphorylates Mitogen-Activated Protein Kinase Kinase (MAPKK) which finally phosphorylates a MAPK [2]. The MAPK may either directly elicite a cellular action or phosphorylate an effector protein that will elicite a cellular response [3].
References
- ↑ Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.
- ↑ Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.
- ↑ Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4), 954–65.