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''' | '''Primase''' is a [[RNA Polymerase|RNA polymerase]] which is responsibe for the synthesis for a short peice of [[RNA|RNA]] which is then able to act as a [[primer|primer]] in [[DNA replication|DNA synthesis]]. The synthesised [[RNA primer|RNA primer]] is very small in size (approximately 5 nucleotides long) and synthesis of the primer can be iniated without the presence of another primer. The primer is complementary to a section of [[DNA|DNA]] and hence binds to it, thus allowing [[DNA polymerase III|DNA polymerase III]] to iniate synthesis of new DNA in the 5' to 3' direction. At a later stage of DNA synthesis the primer is removed and replaced by DNA (for example this is done on the lagging starnd of DNA by [[DNA polymerase I|DNA polymerase I]] which contins an exonucleas enzyme) <ref>Berg J.M., Tymoczko J.L., Styer L. (2012) Biochemistry, 7th edition, New York, W.H Freeman.</ref>.<br> | ||
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Revision as of 16:08, 29 November 2012
Primase is a RNA polymerase which is responsibe for the synthesis for a short peice of RNA which is then able to act as a primer in DNA synthesis. The synthesised RNA primer is very small in size (approximately 5 nucleotides long) and synthesis of the primer can be iniated without the presence of another primer. The primer is complementary to a section of DNA and hence binds to it, thus allowing DNA polymerase III to iniate synthesis of new DNA in the 5' to 3' direction. At a later stage of DNA synthesis the primer is removed and replaced by DNA (for example this is done on the lagging starnd of DNA by DNA polymerase I which contins an exonucleas enzyme) [1].
References:
- ↑ Berg J.M., Tymoczko J.L., Styer L. (2012) Biochemistry, 7th edition, New York, W.H Freeman.