Antagonist: Difference between revisions
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Pharmacological antagonists can be further characterised as: | Pharmacological antagonists can be further characterised as: | ||
*[[Competitive antagonists|Competitive]] which binds to the binding site of a receptor and can be overcome by increasing the concentration of an [[ | *[[Competitive antagonists|Competitive]] which binds to the binding site of a receptor and can be overcome by increasing the concentration of an [[Agonist|agonist]] (competitor). | ||
*[[Irreversible competitive antagonist|Irreversible competitive]] which forms a [[ | *[[Irreversible competitive antagonist|Irreversible competitive]] which forms a [[Covalent bond|covalent bond]] with the receptor. | ||
*[[Non-competitive antagonist|Non-competitive antagonists]] which blocks the [[ | *[[Non-competitive antagonist|Non-competitive antagonists]] which blocks the [[Signal transduction|signal transduction]] event of the [[Receptor|receptor]]. | ||
A pharmacalogical example of an antagonist is [[Tamoxifen|Tamoxifen]], a drug which acts on estrogen receptor. | A pharmacalogical example of an antagonist is [[Tamoxifen|Tamoxifen]], a drug which acts on [[Oestrogen|estrogen]] receptor. See also [[Agonist|agonist]]. | ||
Revision as of 14:05, 19 October 2013
A compound (usually synthetic) that inhibits the action of its natural counterpart by binding to a receptor or protein. There are three classes of antagonist, chemical, physiological and pharmacological.
Pharmacological antagonists can be further characterised as:
- Competitive which binds to the binding site of a receptor and can be overcome by increasing the concentration of an agonist (competitor).
- Irreversible competitive which forms a covalent bond with the receptor.
- Non-competitive antagonists which blocks the signal transduction event of the receptor.
A pharmacalogical example of an antagonist is Tamoxifen, a drug which acts on estrogen receptor. See also agonist.