MAP kinase cascade: Difference between revisions
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The MAP kinase cascade is made up of three components: | The MAP kinase cascade is made up of three components:<br> | ||
<br> | #[[MAP kinase kinase kinase|MAP kinase kinase kinase]] (MAPKKK) or otherwise known as [[Raf|Raf]]. | ||
#[[MAP kinase kinase|MAP kinase kinase]] (MAPKK) or otherwise known as [[Mek|Mek]]. | |||
#[[MAP kinase|MAP kinase]] (MAPK) or otherwise known as [[Erk|Erk]].<br> | |||
Firstly an activated [[Ras|Ras]] protein triggers the Map kinase cascade and then the signal is passed on from one component to the next by phosphorylating the next component in line and therefore activating it. This is the step by step process:<br> | |||
Firstly an activated Ras protein triggers the Map kinase cascade and then the signal is passed on from one component to the next by phosphorylating the next component in line and therefore activating it. This is the step by step process: | |||
<br> | |||
#MAPKKK 'receives the signal' from the Ras and then phosphorylates and activates MAPKK. | #MAPKKK 'receives the signal' from the Ras and then phosphorylates and activates MAPKK. | ||
#MAPKK then phosphorylates and activates MAPK. | #MAPKK then phosphorylates and activates MAPK. | ||
#The MAPK can then pass on the signal to other appropriate proteins so that it is carried to its final destination and eventually lead to a response to the initial signal | #The MAPK can then pass on the signal to other appropriate proteins so that it is carried to its final destination and eventually lead to a response to the initial signal <ref>Alberts,B., Johnson, A.,Lewis,J.,Raff,M.,Roberts,K. and Walter,P. (2007) Molecular Biology of The Cell, 5th editiion, Garland Science, p928-929</ref>.<br> | ||
<br> | |||
=== References === | === References === | ||
<references /> | <references /> | ||
Latest revision as of 01:56, 29 November 2013
The MAP kinase cascade is made up of three components:
- MAP kinase kinase kinase (MAPKKK) or otherwise known as Raf.
- MAP kinase kinase (MAPKK) or otherwise known as Mek.
- MAP kinase (MAPK) or otherwise known as Erk.
Firstly an activated Ras protein triggers the Map kinase cascade and then the signal is passed on from one component to the next by phosphorylating the next component in line and therefore activating it. This is the step by step process:
- MAPKKK 'receives the signal' from the Ras and then phosphorylates and activates MAPKK.
- MAPKK then phosphorylates and activates MAPK.
- The MAPK can then pass on the signal to other appropriate proteins so that it is carried to its final destination and eventually lead to a response to the initial signal [1].
References
- ↑ Alberts,B., Johnson, A.,Lewis,J.,Raff,M.,Roberts,K. and Walter,P. (2007) Molecular Biology of The Cell, 5th editiion, Garland Science, p928-929