Raf
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Raf also known as MAP Kinase Kinase Kinase is the first kinase in the phosphorylation cascade. Raf is triggered by Ras, which activates Raf through a conformational change. Once Raf is phosphorylated, it then goes on to phosphorylate Mek[1].
References
- ↑ Alberts et al. (2008). Molecular biology of the cell. 5th edition. New York, Garland Science. 928-929.