From The School of Biomedical Sciences Wiki
Raf also known as MAP Kinase Kinase Kinase is the first kinase in the phosphorylation cascade. Raf is triggered by Ras, which activates Raf through a conformational change. Once Raf is phosphorylated, it then goes on to phosphorylate Mek.
- ↑ Alberts et al. (2008). Molecular biology of the cell. 5th edition. New York, Garland Science. 928-929.