Asparagine: Difference between revisions

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Asparagine is a non-essential amino acid. Its abbreviations are Asn or N, and its codons are AAU or AAC.  
Asparagine is a non-essential amino acid. Its abbreviations are Asn or N, and its codons are AAU or AAC.  


It provides an important site for asparagine-linked glycosylation (N-glycosylation) within peptides <ref>Kenneth W. Joy, Robert J. Ireland and Peter J. Lea, 'Asparagine Synthesis in Pea Leaves, and the Occurrence of an Asparagine Synthetase Inhibitor' Plant Physiology (1983) 73:165-168</ref>.  
It provides an important site for asparagine-linked glycosylation (N-glycosylation) within peptides <ref>Kenneth W. Joy, Robert J. Ireland and Peter J. Lea, 'Asparagine Synthesis in Pea Leaves, and the Occurrence of an Asparagine Synthetase Inhibitor' Plant Physiology (1983) 73:165-168</ref><ref>Berg, J. M., Tymoczko, J. L., &amp; Stryer, L. (2002). Biochemistry (5th ed.). New York: W.H. Freeman.</ref>.  


<br> '''<u>Synthesis</u>'''  
<br> '''<u>Synthesis</u>'''  
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[[Image:Asparagine.png]]
[[Image:Asparagine.png]]  


=== References  ===
=== References  ===


Berg, J. M., Tymoczko, J. L., &amp; Stryer, L. (2002). Biochemistry (5th ed.). New York: W.H. Freeman.<br>
<references /><br>

Latest revision as of 03:44, 30 November 2013

Asparagine is a non-essential amino acid. Its abbreviations are Asn or N, and its codons are AAU or AAC.

It provides an important site for asparagine-linked glycosylation (N-glycosylation) within peptides [1][2].


Synthesis

                          (transaminase)                                (asparagine synthase)

Oxaloacetate                   ⇒                        Aspartate                  ⇒                     Asparagine

                 glutamate   →  alpha-ketoglutarate               glutamine  →     glutamate

                                                                                     ATP   →  AMP + PPi


References

  1. Kenneth W. Joy, Robert J. Ireland and Peter J. Lea, 'Asparagine Synthesis in Pea Leaves, and the Occurrence of an Asparagine Synthetase Inhibitor' Plant Physiology (1983) 73:165-168
  2. Berg, J. M., Tymoczko, J. L., & Stryer, L. (2002). Biochemistry (5th ed.). New York: W.H. Freeman.