PTBI: Difference between revisions
Jump to navigation
Jump to search
Created page with "PTB (phosphotyrosine-binding domain) has a compact, 7-stranded beta-sandwich structure which is capped by a C-terminal helix, and is located near the N terminus. Along with PH d..." |
No edit summary |
||
| (One intermediate revision by one other user not shown) | |||
| Line 1: | Line 1: | ||
PTBI (IRS1-like) | |||
PTB ([[phosphotyrosine-binding domain|phosphotyrosine-binding domain]]) has a compact, 7-stranded beta-sandwich structure which is capped by a C-terminal helix, and is located near the N terminus<ref>Zhou, M., Huang, B., Olejniczak, E., Meadows, R., Shuker, S., Miyazaki, M., Trüb, T., Shoelson, S. and Fesik, S. (1996). Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain. Nat Struct Mol Biol, 3(4), pp.388-393.</ref>. | |||
Along with [[PH_domain|PH domains]], they facilitate interaction with the activated [[tyrosine-phosphorylated insulin receptor|tyrosine-phosphorylated insulin receptor]] in ISR-1<ref>Zhou, M., Huang, B., Olejniczak, E., Meadows, R., Shuker, S., Miyazaki, M., Trüb, T., Shoelson, S. and Fesik, S. (1996). Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain. Nat Struct Mol Biol, 3(4), pp.388-393.</ref>.<br> | |||
=== References === | |||
<references /><br> | |||
Latest revision as of 20:09, 20 October 2015
PTBI (IRS1-like)
PTB (phosphotyrosine-binding domain) has a compact, 7-stranded beta-sandwich structure which is capped by a C-terminal helix, and is located near the N terminus[1].
Along with PH domains, they facilitate interaction with the activated tyrosine-phosphorylated insulin receptor in ISR-1[2].
References
- ↑ Zhou, M., Huang, B., Olejniczak, E., Meadows, R., Shuker, S., Miyazaki, M., Trüb, T., Shoelson, S. and Fesik, S. (1996). Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain. Nat Struct Mol Biol, 3(4), pp.388-393.
- ↑ Zhou, M., Huang, B., Olejniczak, E., Meadows, R., Shuker, S., Miyazaki, M., Trüb, T., Shoelson, S. and Fesik, S. (1996). Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain. Nat Struct Mol Biol, 3(4), pp.388-393.