ABC superfamily: Difference between revisions

From The School of Biomedical Sciences Wiki
Jump to navigation Jump to search
Created page with 'ABC stands for ATP binding cassette.  All members have two domains which bind and in many cases hydrolyse ATP.  These domains are conserved th…'
 
mNo edit summary
 
(8 intermediate revisions by 5 users not shown)
Line 1: Line 1:
ABC stands for [[ATP|ATP]] binding cassette.  All members have two domains which bind and in many cases hydrolyse [[ATP|ATP]].  These domains are conserved throughout the family of proteins.
[[ATP|ATP]]-binding cassette transporters are transmembrane proteins that use energy from [[ATP|ATP]] to carry out biological processes such as translocation of substrate across membranes as well as [[DNA|DNA]] and [[RNA|RNA]] repair<br>


The ABC superfamily is the largest family of membrane proteins.
ABC proteins are the largest family of [[Transmembrane proteins|transmembrane proteins]], they contain two [[Nucleotide|nucleotide]] binding domains, located in the [[Cytoplasm|cytoplasm]], and two transmembrane domains<ref>Dean M. The Human ATP-Binding Cassette (ABC) Transporter Superfamily [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2002 Nov 18. Available from: http://www.ncbi.nlm.nih.gov/books/NBK3/</ref>.&nbsp;<br>An example of ABC superfamily is the cystic fibrosis transmembrane conductance regulator. Yet, it is very exclusive as it is an ion pump and not an ATPase pump which most ABCs are.&nbsp;<br>


[[CFTR|CFTR]] and [[P-glycoprotein|P-glycoprotein]] are both examples of ABC superfamily proteins.&nbsp;<ref>Alberts, Bruce (2008), Molecular Biology Of The Cell, 5th edition, Garland Science</ref>
=== Reference  ===
 
=== References ===


<references />
<references />

Latest revision as of 19:42, 19 October 2014

ATP-binding cassette transporters are transmembrane proteins that use energy from ATP to carry out biological processes such as translocation of substrate across membranes as well as DNA and RNA repair

ABC proteins are the largest family of transmembrane proteins, they contain two nucleotide binding domains, located in the cytoplasm, and two transmembrane domains[1]. 
An example of ABC superfamily is the cystic fibrosis transmembrane conductance regulator. Yet, it is very exclusive as it is an ion pump and not an ATPase pump which most ABCs are. 

Reference

  1. ↑ Dean M. The Human ATP-Binding Cassette (ABC) Transporter Superfamily [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2002 Nov 18. Available from: http://www.ncbi.nlm.nih.gov/books/NBK3/
Retrieved from "https://teaching.ncl.ac.uk/bms/wiki//index.php?title=ABC_superfamily&oldid=11034"