Macrophage: Difference between revisions
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Macrophages are pattern recognition receptors (PPR's) which are involved in the [[Innate immune system|innate immune system]] of organisms, these phagocytic [[White blood cells|white blood cells]] are the first to respond to infection. They also play a role in [[Immune response|inflammation of]] tissues. When activated, they become [[Antigen presenting cells|antigen presenting cells]] as well as producing [[Chemokines|chemokines]] and [[Cytokines|cytokines]]<ref>Janeways ImmunoBiology, Murphy K. et al., 2008, 7th ed.</ref>. They work by engulfing [[Pathogens|pathogens]] detected by the immune system and engulfing them. The newly engulfed pathogen is then bound to a [[Phagosome|phagosome]] and [[Lysosome|lysosome]] which release enzymes and toxic chemicals that digest the pathogen. | |||
They also play a role in the degradation of old or ruptured red blood cells as well as the activation of [[T-cells|T-cells]]<ref>D Sadava, DM Hillis, HC Heller, M Berenbaum. Life: The Science of Biology. 10th Edition. 2014. Sinauer</ref>. | |||
=== References === | === References === | ||
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Latest revision as of 20:38, 5 December 2017
Macrophages are pattern recognition receptors (PPR's) which are involved in the innate immune system of organisms, these phagocytic white blood cells are the first to respond to infection. They also play a role in inflammation of tissues. When activated, they become antigen presenting cells as well as producing chemokines and cytokines[1]. They work by engulfing pathogens detected by the immune system and engulfing them. The newly engulfed pathogen is then bound to a phagosome and lysosome which release enzymes and toxic chemicals that digest the pathogen.
They also play a role in the degradation of old or ruptured red blood cells as well as the activation of T-cells[2].