Chemokines are chemotactic cytokines that control the movement of immune cells and are involved in acute inflammation. They control cell migration by interacting with two receptors: G-protein linked and cell surface (extracellular) receptors. Chemokines stimulate the movement of leukocytes to areas of the body with inflammation.
In humans, there are around 45 chemokines and 22 chemokine receptors.
- ↑ 1.0 1.1 Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defence and immunity. Annual Review of Immunology (2014) 32, 659–702.
- ↑ Baggiolini M. Chemokines and Leukocyte Traffic. Nature (1998) 392, 565-568.
- ↑ Kufarena I, Salanga CL and Handel TM. Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies. Immunology and Cell Biology (2015) 93, 372–383.