Chemokines

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Chemokines are chemotactic cytokines that control the movement of immune cells and are involved in acute inflammation[1]. They control cell migration by interacting with two receptors: G-protein linked and cell surface (extracellular) receptors[1]. Chemokines stimulate the movement of leukocytes to areas of the body with inflammation[2].

In humans, there are around 45 chemokines and 22 chemokine receptors[3].

References

  1. 1.0 1.1 Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defence and immunity. Annual Review of Immunology (2014) 32, 659–702.
  2. Baggiolini M. Chemokines and Leukocyte Traffic. Nature (1998) 392, 565-568.
  3. Kufarena I, Salanga CL and Handel TM. Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies. Immunology and Cell Biology (2015) 93, 372–383.
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