Initiation factor: Difference between revisions
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Initiation factors are proteins that enhance the binding affinity of the various [[Translation|translational]] components. | |||
== Types of Initiation factors in ''E. coli''<br> == | === Types of Initiation factors in ''E. coli''<br> === | ||
IF1<br> | IF1<br> | ||
IF2 <br> | IF2 <br> | ||
IF3<br> | IF3<br> | ||
== Role of Initiation factors<br> == | === Role of Initiation factors<br> === | ||
IF1 - Stabilizes 30S subunit<br> | IF1 - Stabilizes 30S subunit<br> | ||
IF2 - Binds f-met-tRNA to 30S-mRNA complex ; binds to GTP and stimulates hydrolysis<br> | IF2 - Binds f-met-tRNA to 30S-mRNA complex ; binds to GTP and stimulates [[Hydrolysis|hydrolysis<br>]] | ||
IF3 - Binds 30S subunit to mRNA ; dissociates monosomes into subunits following termination<br> | IF3 - Binds 30S subunit to mRNA ; dissociates monosomes into subunits following [[termination|termination]]<ref>William S. Klug, Michael R. Cummings, Charlotte Spencer, Michael Palladino (2014). Concepts of Genetics Tenth Edition</ref><br> | ||
=== <u></u>References === | |||
<references /><br> | |||
Latest revision as of 11:16, 5 December 2017
Initiation factors are proteins that enhance the binding affinity of the various translational components.
Types of Initiation factors in E. coli
IF1
IF2
IF3
Role of Initiation factors
IF1 - Stabilizes 30S subunit
IF2 - Binds f-met-tRNA to 30S-mRNA complex ; binds to GTP and stimulates hydrolysis
IF3 - Binds 30S subunit to mRNA ; dissociates monosomes into subunits following termination[1]
References
- ↑ William S. Klug, Michael R. Cummings, Charlotte Spencer, Michael Palladino (2014). Concepts of Genetics Tenth Edition