GLUT4: Difference between revisions
An introduction to the role of GLUT4 glucose Transporter proteins in skeletal muscle cells. |
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[[Glucose|Glucose]] is a source of energy for the human body. [[Skeletal Muscle|Skeletal Muscle]] cells and [[adipose tissue|adipose tissue]] cells play a key role in the maintenance of [[glucose homeostasis|glucose homeostasis]] by its ability to uptake and store glucose as a molecule called [[glycogen|glycogen]] which is the storage molecule for glucose. It does this by very specific transporter proteins called GLUT4 glucose transporters which is 1 of the 13 sugar transporter proteins. GLUT4 glucose transporters are expressed via stimulation from [[Insulin|Insulin]] and when unstimulated are removed from the surface and into the [[plasma membrane|plasma membrane]] of the skeletal muscle cells or adipose tissue cells. The GLUT4 glucose transporters are again expressed when the body's blood sugar increases which stimulates the [[pancreas beta cells|pancreas beta cells]] to release insulin and the insulin then stimulates the skeletal muscle cells to express GLUT4 receptors to transport glucose and store it as glycogen to bring blood/sugar levels down and maintain glucose homeostasis<ref>https://www.ncbi.nlm.nih.gov/pubmed/17403369</ref><ref>https://www.cell.com/cell-metabolism/fulltext/S1550-4131(07)00067-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413107000678%3Fshowall%3Dtrue</ref>. | |||
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Latest revision as of 06:03, 24 October 2018
Glucose is a source of energy for the human body. Skeletal Muscle cells and adipose tissue cells play a key role in the maintenance of glucose homeostasis by its ability to uptake and store glucose as a molecule called glycogen which is the storage molecule for glucose. It does this by very specific transporter proteins called GLUT4 glucose transporters which is 1 of the 13 sugar transporter proteins. GLUT4 glucose transporters are expressed via stimulation from Insulin and when unstimulated are removed from the surface and into the plasma membrane of the skeletal muscle cells or adipose tissue cells. The GLUT4 glucose transporters are again expressed when the body's blood sugar increases which stimulates the pancreas beta cells to release insulin and the insulin then stimulates the skeletal muscle cells to express GLUT4 receptors to transport glucose and store it as glycogen to bring blood/sugar levels down and maintain glucose homeostasis[1][2].