GLUT3: Difference between revisions
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GLUT3 is a [[ | GLUT3 is a [[Glucose transporter|glucose transporter]] within cell membranes. It is one of 14 Na<sup>+</sup> independent facilitated diffusion transporters<ref>Cura, Anthony J., and Anthony Carruthers. “The Role of Monosaccharide Transport Proteins in Carbohydrate Assimilation, Distribution, Metabolism and Homeostasis.” Comprehensive Physiology 2.2 (2012): 863–914. PMC. Web. 6 Dec. 2017.</ref>, termed [[GLUT1|GLUT1]] to [[GLUT14|GLUT14]]. As it is a facilitated diffusion transporter, it relies on a concentration gradient for transport of glucose. | ||
GLUT3 binds to [[ | GLUT3 binds to [[Glucose|glucose]] in the extracellular space (e.g. [[Blood|blood]]) which induces a conformational change. This conformational change transports the glucose across the cell membrane. | ||
GLUT3 is primarily involved in glucose transport for neurones and, unlike some transporters, principally tranports glucose to within the cells, rather than bidirectionally. | GLUT3 is primarily involved in glucose transport for neurones<ref>Expression of two glucose transporters, GLUT1 and GLUT3, in cultured cerebellar neurons: Evidence for neuron-specific expression of GLUT3.fckLRF. Maher, T. M. Davies-Hill, P. G. Lysko, R. C. Henneberry, I. A. SimpsonfckLRMol Cell Neurosci. 1991 Aug; 2(4): 351–360.</ref> and, unlike some transporters, principally tranports glucose to within the cells, rather than bidirectionally. | ||
Revision as of 10:39, 6 December 2017
GLUT3 is a glucose transporter within cell membranes. It is one of 14 Na+ independent facilitated diffusion transporters[1], termed GLUT1 to GLUT14. As it is a facilitated diffusion transporter, it relies on a concentration gradient for transport of glucose.
GLUT3 binds to glucose in the extracellular space (e.g. blood) which induces a conformational change. This conformational change transports the glucose across the cell membrane.
GLUT3 is primarily involved in glucose transport for neurones[2] and, unlike some transporters, principally tranports glucose to within the cells, rather than bidirectionally.
- ↑ Cura, Anthony J., and Anthony Carruthers. “The Role of Monosaccharide Transport Proteins in Carbohydrate Assimilation, Distribution, Metabolism and Homeostasis.” Comprehensive Physiology 2.2 (2012): 863–914. PMC. Web. 6 Dec. 2017.
- ↑ Expression of two glucose transporters, GLUT1 and GLUT3, in cultured cerebellar neurons: Evidence for neuron-specific expression of GLUT3.fckLRF. Maher, T. M. Davies-Hill, P. G. Lysko, R. C. Henneberry, I. A. SimpsonfckLRMol Cell Neurosci. 1991 Aug; 2(4): 351–360.