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SSRI is an acronym for Selective Serotonin Reuptake Inhibitor. SSRIs are [[Antidepressant|antidepressants]] <ref name="[1]">Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.</ref> that work by inhibiting [[Serotonin|serotonin]] (a.k.a. 5-hydroxytryptamine or 5-HT) re-uptake. Unlike [[Tricyclic antidepressants|tricyclic antidepressants]] (TCAs) and [[Serotonin/norepinephrine reuptake inhibitors|serotonin/norepinephrine reuptake inhibitors]] (SNRIs), SSRIs have greater selectivity for the serotonin transporter than to norepinephrine transporter (Whalen, Finkel & Panavelil, 2015, p. 136)<ref name="[2]">WHALEN, K., FINKEL, R. | SSRI is an acronym for Selective Serotonin Reuptake Inhibitor. SSRIs are [[Antidepressant|antidepressants]] <ref name="[1]">Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.</ref> that work by inhibiting [[Serotonin|serotonin]] (a.k.a. 5-hydroxytryptamine or 5-HT) re-uptake. Unlike [[Tricyclic antidepressants|tricyclic antidepressants]] (TCAs) and [[Serotonin/norepinephrine reuptake inhibitors|serotonin/norepinephrine reuptake inhibitors]] (SNRIs), SSRIs have greater selectivity for the serotonin transporter than to norepinephrine transporter (Whalen, Finkel & Panavelil, 2015, p. 136)<ref name="[2]">WHALEN, K., FINKEL, R. and PANAVELIL, T.A., (2015) Lippincott Illustrated Reviews: Pharmacology. 6th Ed. Philadelphia: Wolters Kluwer.</ref>. Therefore, SSRIs are more specific, inhibiting only serotonin reuptake (Whalen, Finkel & Panavelil, 2015, p. 136)<ref name="[2]">WHALEN, K., FINKEL, R. and PANAVELIL, T.A., (2015) Lippincott Illustrated Reviews: Pharmacology. 6th Ed. Philadelphia: Wolters Kluwer.</ref>. This in turn will increase the serotonin level across the synaptic cleft. <br> | ||
Some examples of SSRIs include [[Fluoxetine|fluoxetine]], [[Paroxetine|paroxetine]] and [[Sertraline|sertraline]] <ref name="[1]">Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.</ref>. | Some examples of SSRIs include [[Fluoxetine|fluoxetine]], [[Paroxetine|paroxetine]] and [[Sertraline|sertraline]] <ref name="[1]">Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.</ref>. | ||
Revision as of 14:14, 18 October 2015
SSRI is an acronym for Selective Serotonin Reuptake Inhibitor. SSRIs are antidepressants [1] that work by inhibiting serotonin (a.k.a. 5-hydroxytryptamine or 5-HT) re-uptake. Unlike tricyclic antidepressants (TCAs) and serotonin/norepinephrine reuptake inhibitors (SNRIs), SSRIs have greater selectivity for the serotonin transporter than to norepinephrine transporter (Whalen, Finkel & Panavelil, 2015, p. 136)[2]. Therefore, SSRIs are more specific, inhibiting only serotonin reuptake (Whalen, Finkel & Panavelil, 2015, p. 136)[2]. This in turn will increase the serotonin level across the synaptic cleft.
Some examples of SSRIs include fluoxetine, paroxetine and sertraline [1].