SSRI

From The School of Biomedical Sciences Wiki
Jump to: navigation, search

SSRI is an acronym for Selective Serotonin Reuptake Inhibitor. SSRIs are antidepressants [1] that work by inhibiting serotonin (a.k.a. 5-hydroxytryptamine or 5-HT) re-uptake. Unlike tricyclic antidepressants (TCAs) and serotonin/norepinephrine reuptake inhibitors (SNRIs), SSRIs have greater selectivity for the serotonin transporter than to norepinephrine transporter [2]. Therefore, SSRIs are more specific, inhibiting only serotonin reuptake [2]. This in turn will increase the serotonin level across the synaptic cleft.

Some examples of SSRIs include fluoxetine (also known by the trade name Prozac), paroxetine and sertraline [1].

SSRIs can have a variety of side effects on a patient, including drowsiness, nausea, insomnia, dry mouth and agitation.

References

  1. 1.0 1.1 Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.
  2. 2.0 2.1 WHALEN, K., FINKEL, R. and PANAVELIL, T.A., (2015) Lippincott Illustrated Reviews: Pharmacology. 6th Ed. Philadelphia: Wolters Kluwer.
Personal tools
Namespaces
Variants
Actions
Navigation
Toolbox