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A Tetrasomy is a kind of [[Aneuploidy|aneuploidy]] that implicates an extra [[Chromosome|chromosome ]] | A Tetrasomy is a kind of [[Aneuploidy|aneuploidy]] that implicates an extra [[Chromosome|chromosome pair]] as a result of the presence of four copies of a specific [[Chromosome|chromosome]], in an otherwise [[Diploid cell|diploid cell]]. ([[Tetrasomic|Tetrasomic]] Chromosome Formula 2N + 2) <ref>http://ghr.nlm.nih.gov/glossary=tetrasomy</ref><ref name="null">Genetics, Rusell (Fifth Edition), Peter J. Rusell). P (207-209)</ref>. | ||
Tetrasomy occurs due to [[Nondisjunction|nondisjunction]] in [[Meiosis|meiosis]] when both parents produce a [[Gamete|gamete ]] | Tetrasomy occurs due to [[Nondisjunction|nondisjunction]] in [[Meiosis|meiosis]] when both parents produce a [[Gamete|gamete each]] that presents two copies of an individual [[Chromosome|chromosome]], while all other [[Chromosomes|chromosomes in]] the set present only one copy. The result is a [[FETUS|fetus]] that contains 48 chromosomes, instead of the common 46 chromosomes <ref>Genetics, Rusell (Fifth Edition), Peter J. Rusell). P (207-209)</ref>.<br> | ||
Examples of [[TETRASOMIES|tetrasomies abnormalities]] for [[Autosomes|autosomes]] and for [[Sex chromosomes|sex chromosomes]] found in humans: | |||
=== Sex-chromosome tetrasomies: <ref>https://en.wikipedia.org/wiki/Tetrasomy</ref> === | |||
*48, XXYY and 48, XXXY: variations of the [[Klinefelter syndrome|Klinefelter syndrome]] (occur in 1 in 18,000–50,000 male births) <ref>https://en.wikipedia.org/wiki/Klinefelter_syndrome</ref>. | |||
*48, XXYY and 48, XXXY: variations of the [[ | |||
*[[XXXX syndrome|48, XXXX syndrome]] | *[[XXXX syndrome|48, XXXX syndrome]] | ||
== | === Autosomal tetrasomies<ref>https://en.wikipedia.org/wiki/Tetrasomy</ref> === | ||
*[[Cat eye syndrome|Cat eye syndrome]] | |||
*[[Pallister-Killian syndrome|Pallister-Killian syndrome ]](tetrasomy 12p) | |||
*[[Tetrasomy 18p|Tetrasomy 18p]] | |||
*[[Tetrasomy 9p|Tetrasomy 9p]]<br> | |||
=== References === | === References === | ||
<references /> | <references /> | ||
Latest revision as of 13:06, 30 November 2015
A Tetrasomy is a kind of aneuploidy that implicates an extra chromosome pair as a result of the presence of four copies of a specific chromosome, in an otherwise diploid cell. (Tetrasomic Chromosome Formula 2N + 2) [1][2].
Tetrasomy occurs due to nondisjunction in meiosis when both parents produce a gamete each that presents two copies of an individual chromosome, while all other chromosomes in the set present only one copy. The result is a fetus that contains 48 chromosomes, instead of the common 46 chromosomes [3].
Examples of tetrasomies abnormalities for autosomes and for sex chromosomes found in humans:
Sex-chromosome tetrasomies: [4]
- 48, XXYY and 48, XXXY: variations of the Klinefelter syndrome (occur in 1 in 18,000–50,000 male births) [5].
- 48, XXXX syndrome
Autosomal tetrasomies[6]
- Cat eye syndrome
- Pallister-Killian syndrome (tetrasomy 12p)
- Tetrasomy 18p
- Tetrasomy 9p
References
- ↑ http://ghr.nlm.nih.gov/glossary=tetrasomy
- ↑ Genetics, Rusell (Fifth Edition), Peter J. Rusell). P (207-209)
- ↑ Genetics, Rusell (Fifth Edition), Peter J. Rusell). P (207-209)
- ↑ https://en.wikipedia.org/wiki/Tetrasomy
- ↑ https://en.wikipedia.org/wiki/Klinefelter_syndrome
- ↑ https://en.wikipedia.org/wiki/Tetrasomy