MHC Molecules: Difference between revisions
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MHC Molecules play a key role in the presentation of antigens. The foreign protein must be processed into a peptide before it can be presented by MHC. This processing occurs in the Proteasome of the Cell. There are 2 types of MHC Molecule; Class 1 MHC & Class 2 MHC. | MHC Molecules play a key role in the presentation of [[Antigens|antigens]]. The foreign [[Proteins|protein]] must be processed into a [[Peptide|peptide]] before it can be presented by MHC. This processing occurs in the [[Proteasome|proteasome]] of the [[Cell|cell]]. There are 2 types of MHC Molecule; Class 1 MHC & Class 2 MHC. <br> | ||
=== MHC Class 1 === | |||
MHC Class 1 molecules are expressed in all nucleated cells. These are involved in the presentation of endogenous [[Antigens|antigens]] (those found intracellularly). Presentation of these endogenous antigens is recognised by [[Cytotoxic T cells|Cytotoxic T cells]] that destroy the antigen via a mechanism involving the use of [[Granzyme|Granzyme]] and [[Perfornin|Perfornin]].<br> | |||
MHC | === MHC Class 2 === | ||
MHC Class 2 are expressed in professional [[Antigen presenting cells|antigen presenting cells]] such as [[Macrophage|macrophages]] and [[B Cells|B Cells]]. They present exogenous [[Antigens|antigens]] (those made outside the cell). They bind peptides 18-20 [[Amino_acids|amino acids]] long. | |||
MHC Class 2 are expressed in professional antigen presenting cells such as macrophages and B Cells. They present exogenous antigens (those made outside the cell). They bind peptides 18-20 [[ | |||
Revision as of 15:57, 22 November 2010
MHC Molecules play a key role in the presentation of antigens. The foreign protein must be processed into a peptide before it can be presented by MHC. This processing occurs in the proteasome of the cell. There are 2 types of MHC Molecule; Class 1 MHC & Class 2 MHC.
MHC Class 1
MHC Class 1 molecules are expressed in all nucleated cells. These are involved in the presentation of endogenous antigens (those found intracellularly). Presentation of these endogenous antigens is recognised by Cytotoxic T cells that destroy the antigen via a mechanism involving the use of Granzyme and Perfornin.
MHC Class 2
MHC Class 2 are expressed in professional antigen presenting cells such as macrophages and B Cells. They present exogenous antigens (those made outside the cell). They bind peptides 18-20 amino acids long.