Prostacyclin: Difference between revisions

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&nbsp;Prostacyclin (also called PGI<sub>2</sub>) is a [https://en.wikipedia.org/wiki/Prostaglandin prostaglandin] belonging to the&nbsp;[https://en.wikipedia.org/wiki/Eicosanoid eicosanoid]family<sup>1</sup><sup></sup><sup></sup>,<span style="font-size: 13.28px;">&nbsp;produced by intact vascular endothelial cells<sup>2</sup>. When prostacyclin is produced, it prevents platelet adhesion and aggregation so that clots are not unintentionally formed within blood vessels<sup>2</sup>. When the endothelium lining blood vessels is damaged, prostacyclin production is stopped and platelet aggregation occurs, allowing a clot to form and seal the break<sup>2</sup>. Prostacyclin is also a vasodilator<sup>2</sup>.&nbsp;</span>
Prostacyclin (also called PGI<sub>2</sub>) is a [[prostaglandin|prostaglandin]] belonging to the&nbsp;[[eicosanoid|eicosanoid]]&nbsp;family<ref>https://en.wikipedia.org/wiki/Prostacyclin</ref>,<span style="font-size: 13.28px;">&nbsp;produced by intact [[vascular endothelial cells|vascular endothelial cells]]<ref>Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013</ref>. When prostacyclin is produced, it prevents platelet adhesion and aggregation so that clots are not unintentionally formed within [[Blood_vessels|blood vessels]]<ref>Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013</ref>. When the [[Endothelium|endothelium]] lining blood vessels is damaged, prostacyclin production is stopped and [[Platelets|platelet]] aggregation occurs, allowing a clot to form and seal the break<ref>Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013</ref>. Prostacyclin is also a [[vasodilator|vasodilator]]<ref>Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013</ref>.&nbsp;</span>  


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=== References &nbsp; ===


 
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References:&nbsp;
 
 
 
1) https://en.wikipedia.org/wiki/Prostacyclin
 
2) Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013

Latest revision as of 19:11, 18 October 2017

Prostacyclin (also called PGI2) is a prostaglandin belonging to the eicosanoid family[1], produced by intact vascular endothelial cells[2]. When prostacyclin is produced, it prevents platelet adhesion and aggregation so that clots are not unintentionally formed within blood vessels[3]. When the endothelium lining blood vessels is damaged, prostacyclin production is stopped and platelet aggregation occurs, allowing a clot to form and seal the break[4]. Prostacyclin is also a vasodilator[5]. 

References  

  1. ↑ https://en.wikipedia.org/wiki/Prostacyclin
  2. ↑ Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013
  3. ↑ Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013
  4. ↑ Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013
  5. ↑ Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013


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