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Lipopolysaccharides (LPS) are glycosylated phospholipids that are found in the outer leaflet of the outer membrane of Gram negative bacteria<ref>Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of The Cell. 6th Ed, New York: Garland Science. 2014</ref>. They assist in the bacteria's function of protecting against foreign materials such as antibiotics by blocking them from entering the cell<ref>Miller SI. Antibiotic Resistance and Regulation of the Gram-Negative Bacterial Outer Membrane Barrier by Host Innate Immune Molecules. 2016 [cited 15/11/18]; Available from:https://mbio.asm.org/content/7/5/e01541-16</ref>. Although LPS aids the bacteria in defending against antibiotics, they can lead to the production of new antibiotics that can target the processes that lead to the formation of LPS in the outer membrane: the outer membrane will not be as stable or effective as normal if the LPS are not correctly synthesised<ref>Epand RM, Walker C, Epand RF, Magarvey NA. Molecular mechanisms of membrane targeting antibiotics. 2015 [cited 15/11/18]; Available from: https://www.sciencedirect.com/science/article/pii/S0005273615003582</ref>. | Lipopolysaccharides (LPS) are glycosylated phospholipids that are found in the outer leaflet of the outer membrane of [[Gram-negative|Gram negative]] bacteria<ref>Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of The Cell. 6th Ed, New York: Garland Science. 2014</ref>. They assist in the bacteria's function of protecting against foreign materials such as antibiotics by blocking them from entering the cell<ref>Miller SI. Antibiotic Resistance and Regulation of the Gram-Negative Bacterial Outer Membrane Barrier by Host Innate Immune Molecules. 2016 [cited 15/11/18]; Available from:https://mbio.asm.org/content/7/5/e01541-16</ref>. Although LPS aids the bacteria in defending against antibiotics, they can lead to the production of new antibiotics that can target the processes that lead to the formation of LPS in the outer membrane: the outer membrane will not be as stable or effective as normal if the LPS are not correctly synthesised<ref>Epand RM, Walker C, Epand RF, Magarvey NA. Molecular mechanisms of membrane targeting antibiotics. 2015 [cited 15/11/18]; Available from: https://www.sciencedirect.com/science/article/pii/S0005273615003582</ref>. | ||
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Revision as of 14:31, 25 November 2018
Lipopolysaccharides (LPS) are glycosylated phospholipids that are found in the outer leaflet of the outer membrane of Gram negative bacteria[1]. They assist in the bacteria's function of protecting against foreign materials such as antibiotics by blocking them from entering the cell[2]. Although LPS aids the bacteria in defending against antibiotics, they can lead to the production of new antibiotics that can target the processes that lead to the formation of LPS in the outer membrane: the outer membrane will not be as stable or effective as normal if the LPS are not correctly synthesised[3].
References:
- ↑ Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of The Cell. 6th Ed, New York: Garland Science. 2014
- ↑ Miller SI. Antibiotic Resistance and Regulation of the Gram-Negative Bacterial Outer Membrane Barrier by Host Innate Immune Molecules. 2016 [cited 15/11/18]; Available from:https://mbio.asm.org/content/7/5/e01541-16
- ↑ Epand RM, Walker C, Epand RF, Magarvey NA. Molecular mechanisms of membrane targeting antibiotics. 2015 [cited 15/11/18]; Available from: https://www.sciencedirect.com/science/article/pii/S0005273615003582