SSRI: Difference between revisions

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SSRI stands for Selective Serotonin Re-uptake Inhibitor and these drugs are used as antidepressants&nbsp;<ref>Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.</ref>.&nbsp;By inhibiting&nbsp;[[Serotonin|serotonin]] re-uptake, the drugs increase&nbsp;the serotonin level across the synaptic cleft.&nbsp;Drugs such as [[fluoxetine|fluoxetine]], [[paroxetine|paroxetine]] and [[sertraline|sertraline]] are examples of SSRIs <ref>Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.</ref>.
SSRI is an acronym for Selective Serotonin Reuptake Inhibitor. SSRIs are&nbsp;[[Antidepressant|antidepressants]]&nbsp;<ref>Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.</ref>&nbsp;that work&nbsp;by inhibiting&nbsp;[[Serotonin|serotonin]]&nbsp;(a.k.a. 5-hydroxytryptophan or 5-HT) re-uptake. Unlike [[Tricyclic antidepressants|tricyclic antidepressants]] (TCAs) and serotonin/norepinephrine reuptake inhibitors (SNRIs), SSRIs have greater selectivity for the serotonin transporter than to norepinephrine transporter&nbsp;(Whalen, Finkel &amp; Panavelil, 2015, p. 136)<ref>WHALEN, K., FINKEL, R. &amp; PANAVELIL, T.A., (2015) Lippincott Illustrated Reviews: Pharmacology. 6th Ed. Philadelphia: Wolters Kluwer.</ref>. Therefore, SSRIs are more specific, inhibiting only serotonin reuptake&nbsp;(Whalen, Finkel &amp; Panavelil, 2015, p. 136)<ref>WHALEN, K., FINKEL, R. &amp; PANAVELIL, T.A., (2015) Lippincott Illustrated Reviews: Pharmacology. 6th Ed. Philadelphia: Wolters Kluwer.</ref>.&nbsp;This in turn will increase the serotonin level across the synaptic cleft.&nbsp;<br>


=== References ===
Some examples of SSRIs include&nbsp;[[Fluoxetine|fluoxetine]], [[Paroxetine|paroxetine]] and [[Sertraline|sertraline]]&nbsp;<ref>Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.</ref>.
 
=== References ===


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Revision as of 16:25, 17 October 2015

SSRI is an acronym for Selective Serotonin Reuptake Inhibitor. SSRIs are antidepressants [1] that work by inhibiting serotonin (a.k.a. 5-hydroxytryptophan or 5-HT) re-uptake. Unlike tricyclic antidepressants (TCAs) and serotonin/norepinephrine reuptake inhibitors (SNRIs), SSRIs have greater selectivity for the serotonin transporter than to norepinephrine transporter (Whalen, Finkel & Panavelil, 2015, p. 136)[2]. Therefore, SSRIs are more specific, inhibiting only serotonin reuptake (Whalen, Finkel & Panavelil, 2015, p. 136)[3]. This in turn will increase the serotonin level across the synaptic cleft. 

Some examples of SSRIs include fluoxetine, paroxetine and sertraline [4].

References

  1. ↑ Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.
  2. ↑ WHALEN, K., FINKEL, R. & PANAVELIL, T.A., (2015) Lippincott Illustrated Reviews: Pharmacology. 6th Ed. Philadelphia: Wolters Kluwer.
  3. ↑ WHALEN, K., FINKEL, R. & PANAVELIL, T.A., (2015) Lippincott Illustrated Reviews: Pharmacology. 6th Ed. Philadelphia: Wolters Kluwer.
  4. ↑ Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J. and Henderson, G., 2011. Rang and Dale's Pharmacology 7th ed. London:Elsevier Inc.
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