CpG island: Difference between revisions
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[[CpG_island|CpG island]] is a region of [[DNA|DNA]] with higher than usual CG sequence content and mostly found in [[Promoter|promoter]] regions | [[CpG_island|CpG island]] is a region of [[DNA|DNA]] with higher than usual CG sequence content and mostly found in [[Promoter|promoter]] regions <ref>http://www.everythingbio.com/glos/definition.php?word=CpG+island</ref>. Usually unmethylated, CpG islands are important in [[Epigenetics|epigenetic control]] of [[gene expression|gene expression]]. [[Methylation|Methylation]] of these regions can cause [[Cancer|cancer]] and other disease states <ref>Bock C, Paulsen M, Tierling S, Mikeska T, Lengauer T, et al. (2006) CpG Island Methylation in Human Lymphocytes Is Highly Correlated with DNA Sequence, Repeats, and Predicted DNA Structure. PLoS Genet 2(3): e26. doi:10.1371/journal.pgen.0020026</ref>.<br> | ||
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== References == | == References == | ||
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Revision as of 14:23, 15 November 2011
CpG island is a region of DNA with higher than usual CG sequence content and mostly found in promoter regions [1]. Usually unmethylated, CpG islands are important in epigenetic control of gene expression. Methylation of these regions can cause cancer and other disease states [2].
References
- ↑ http://www.everythingbio.com/glos/definition.php?word=CpG+island
- ↑ Bock C, Paulsen M, Tierling S, Mikeska T, Lengauer T, et al. (2006) CpG Island Methylation in Human Lymphocytes Is Highly Correlated with DNA Sequence, Repeats, and Predicted DNA Structure. PLoS Genet 2(3): e26. doi:10.1371/journal.pgen.0020026