Inositol 1,4,5 trisphosphate: Difference between revisions
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Inositol 1,4,5-trisphosphate ( | Inositol 1,4,5-trisphosphate (IP<sub>3</sub>) is a common [[secondary messenger|secondary messenger]] used in [[signal transduction|signal transduction]]. When [[Phosphatidylinositol_4,5-bisphosphate|phosphatidylinositol 4,5-bisphosphate]] (PIP<sub>2</sub>) is hydrolysed by [[phospholipase C|phospholipase C]] it produces IP<sub>3</sub> and [[diacylglycerol|diacylglycerol]] (DAG) <ref>Alberts et al, 2008, Mollecular biology of the Cell, 5th edition, New York, Garland publishing</ref>. IP<sub>3</sub> is soluble so can diffuse through the cell to its [[IP3 receptor|IP<sub>3</sub> receptor]] (InsP3R) on the [[endoplasmic reticulum|endoplasmic reticulum]] or [[sarcoplasmic reticulum|sarcoplasmic reticulum]]. IP<sub>3</sub> receptor acts as a [[calcium|calcium]] ion channel, so once IP<sub>3</sub> is bound it allows the movement of [[Calcium|Ca<sup>2+</sup>]] ions from the endoplasmic reticulum into the cell down their concentration gradient. This influx of calcium causes a [[calcium induced calcium response|calcium induced calcium response]] (CICR) which along with IP<sub>3</sub> helps to activate many more InsP3R <ref>C.H.Heldin &amp; M Purton, 1996, Signal transduction, Chapman &amp; Hall</ref>, leading to a huge amplification of Ca<sup>2+</sup> in the cell.<br> | ||
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Revision as of 21:19, 24 November 2011
Inositol 1,4,5-trisphosphate (IP3) is a common secondary messenger used in signal transduction. When phosphatidylinositol 4,5-bisphosphate (PIP2) is hydrolysed by phospholipase C it produces IP3 and diacylglycerol (DAG) [1]. IP3 is soluble so can diffuse through the cell to its IP3 receptor (InsP3R) on the endoplasmic reticulum or sarcoplasmic reticulum. IP3 receptor acts as a calcium ion channel, so once IP3 is bound it allows the movement of Ca2+ ions from the endoplasmic reticulum into the cell down their concentration gradient. This influx of calcium causes a calcium induced calcium response (CICR) which along with IP3 helps to activate many more InsP3R [2], leading to a huge amplification of Ca2+ in the cell.