MAP Kinase Signalling Module: Difference between revisions
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The mitogen-activated protein (MAP) kinase module is a [[Cell signalling|cell signalling pathway]] that has been highly conserved in [[Eukaryotes|eukaryotes]] and is used, with variations, in many different signalling contexts. It consists of 3 [[Kinase|protein kinase]] components [[Javascript:void(0);/*1350839076955*/|MAP kinase]], [[MAP Kinase Kinase|MAP kinase kinase]] and [[MAP Kinase Kinase Kinase|Map kinase kinase kinase]], also known as Erk, Mek and Raf respectively. On stimulation Raf [[Phosphorylation|phosphorylates]] and activates Mek, which in turn phosphorylates and activates Erk. Each one of these [[Phosphorylation cascade|phosphorylation cascades]] acts to amplify the signal, so a small [[Stimulus|stimulus]] can lead to a large cellular response. After this amplification, Erk is capable of phosphorylating effector [[Protein|proteins]], which on activation/inactivation change their chemical activity within the [[Cell|cell]], or [[Gene regulation|up/down regulate]] the [[Gene expression|expression]] of certain [[Genes|genes]]. | The mitogen-activated protein (MAP) kinase module is a [[Cell signalling|cell signalling pathway]] that has been highly conserved in [[Eukaryotes|eukaryotes]] and is used, with variations, in many different signalling contexts. It consists of 3 [[Kinase|protein kinase]] components [[Javascript:void(0);/*1350839076955*/|MAP kinase]], [[MAP Kinase Kinase|MAP kinase kinase]] and [[MAP Kinase Kinase Kinase|Map kinase kinase kinase]], also known as Erk, Mek and Raf respectively. On stimulation Raf [[Phosphorylation|phosphorylates]] and activates Mek, which in turn phosphorylates and activates Erk. Each one of these [[Phosphorylation cascade|phosphorylation cascades]] acts to amplify the signal, so a small [[Stimulus|stimulus]] can lead to a large cellular response. After this amplification, Erk is capable of phosphorylating effector [[Protein|proteins]], which on activation/inactivation change their chemical activity within the [[Cell|cell]], or [[Gene regulation|up/down regulate]] the [[Gene expression|expression]] of certain [[Genes|genes]].<ref>Alberts et al. 2008. Molecular Biology of the Cell. 5th Edition. Page 929. Garland Science</ref> | ||
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Revision as of 17:15, 21 October 2012
The mitogen-activated protein (MAP) kinase module is a cell signalling pathway that has been highly conserved in eukaryotes and is used, with variations, in many different signalling contexts. It consists of 3 protein kinase components MAP kinase, MAP kinase kinase and Map kinase kinase kinase, also known as Erk, Mek and Raf respectively. On stimulation Raf phosphorylates and activates Mek, which in turn phosphorylates and activates Erk. Each one of these phosphorylation cascades acts to amplify the signal, so a small stimulus can lead to a large cellular response. After this amplification, Erk is capable of phosphorylating effector proteins, which on activation/inactivation change their chemical activity within the cell, or up/down regulate the expression of certain genes.[1]
- ↑ Alberts et al. 2008. Molecular Biology of the Cell. 5th Edition. Page 929. Garland Science