Phosphorylation cascade

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A phosphorylation cascade is organised from many signalling proteins controlled by kinases. A protein kinase is activated by phosphorylation which in turn phosphorylates the next protein kinase in a sequence and so on. As the signal is carried onwards it is amplified and sometimes can spread to other signalling pathways [1]. An example of a phosphorylation cascade is triggered by RAS; a MAP Kinase signalling molecule. Once activated it relays a signal downstream by phosphorylating the protein kinases Raf, Mek and Erk. Raf recieves a signal directly from RAS which in turn phosphorylates and activates Mek, the phosphorylation of Mek can then activate the final kinase in the series Erk [2].

References

  1. Page 929. Alberts, B., Johnson, A., Lewis, J., Raff, M.,Roberts, K., and Watson, J. (2007) Molecular Biology of the Cell, 5th edition, Garland
  2. Page 896. Alberts, B., Johnson, A., Lewis, J., Raff, M.,Roberts, K., and Watson, J. (2007) Molecular Biology of the Cell, 5th edition, Garland.
 
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