Phospholipase C: Difference between revisions
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''' | '''Phospholipase C''', PLC is an [[Enzyme|enzyme]] that produces two second messengers [[Ip3|IP]]<sub>[[Ip3|3]]</sub> and [[Diacylglycerol|diacylglycerol]] ([[Diacylglycerol|DAG]]) by cleavage of inositol phospolipids. [[Ip3|IP]]<sub>[[Ip3|3]]</sub> in turn will trigger the release of [[Calcium|calcium]] from [[Intracellular|intracellular stores]], and [[Diacylglycerol|DAG]] is going to activate [[Protein kinase C|protein kinase C]] ([[Protein kinase C|PKC]]) <ref>Patricia A. Hartz,2003, PHOSPHOLIPASE C, ZETA-1; PLCZ1. OMIM(MIM ID *608075) [online] available at http://www.ncbi.nlm.nih.gov/omim/608075 [Accessed 13 November2010].</ref> <ref>Fukami K, et al.,2010 oct, Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance. Prog Lipid Res. 49(4):429-37 [online] available at http://www.ncbi.nlm.nih.gov/pubmed [Accessed 13 November2010].</ref> <ref>Wang J, et al., 2010 Oct;30. Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol, (10),pp.1976-82 [online] available at http://www.ncbi.nlm.nih.gov/pubmed/20689073 [Accessed 13 November2010].</ref> <ref>Bruce, A. et al., 2008. Molecular biology of the cell, 5th ed, New York: Garland science, pp.909.</ref>. | ||
There is some studies that shows that this enzyme has five groups, each group contains at least two isoforms. | There is some studies that shows that this enzyme has five groups, each group contains at least two isoforms. | ||
#Eta is a superfamily of 1,2 | #Eta is a superfamily of 1,2 | ||
#Beta 1,2,3 and 4 key step in the intracellular transduction of many extracellular signals, are regulated by heterotrimeric G protein-coupled receptors, Gq activates inositol phospholipid signalling pathway which in turn will activate PLC-beta enzyme. | #Beta 1,2,3 and 4 key step in the intracellular transduction of many extracellular signals, are regulated by heterotrimeric G protein-coupled receptors, Gq activates inositol phospholipid signalling pathway which in turn will activate PLC-beta enzyme. | ||
#Delta 1,2,3 | #Delta 1,2,3 | ||
#Gamma 1,2 enzymes are controlled by receptor [[Tyrosine kinases|tyrosine kinases]]. | #Gamma 1,2 enzymes are controlled by receptor [[Tyrosine kinases|tyrosine kinases]]. | ||
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Most of them differ in their activation. Because, they are controlled by different [[Receptors|receptors]]. <br> | Most of them differ in their activation. Because, they are controlled by different [[Receptors|receptors]]. <br> | ||
=== References === | === References === | ||
<references /><br> | <references /><br> | ||
Revision as of 10:17, 14 November 2010
Phospholipase C, PLC is an enzyme that produces two second messengers IP3 and diacylglycerol (DAG) by cleavage of inositol phospolipids. IP3 in turn will trigger the release of calcium from intracellular stores, and DAG is going to activate protein kinase C (PKC) [1] [2] [3] [4].
There is some studies that shows that this enzyme has five groups, each group contains at least two isoforms.
- Eta is a superfamily of 1,2
- Beta 1,2,3 and 4 key step in the intracellular transduction of many extracellular signals, are regulated by heterotrimeric G protein-coupled receptors, Gq activates inositol phospholipid signalling pathway which in turn will activate PLC-beta enzyme.
- Delta 1,2,3
- Gamma 1,2 enzymes are controlled by receptor tyrosine kinases.
- Zeta 1
Most of them differ in their activation. Because, they are controlled by different receptors.
References
- ↑ Patricia A. Hartz,2003, PHOSPHOLIPASE C, ZETA-1; PLCZ1. OMIM(MIM ID *608075) [online] available at http://www.ncbi.nlm.nih.gov/omim/608075 [Accessed 13 November2010].
- ↑ Fukami K, et al.,2010 oct, Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance. Prog Lipid Res. 49(4):429-37 [online] available at http://www.ncbi.nlm.nih.gov/pubmed [Accessed 13 November2010].
- ↑ Wang J, et al., 2010 Oct;30. Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol, (10),pp.1976-82 [online] available at http://www.ncbi.nlm.nih.gov/pubmed/20689073 [Accessed 13 November2010].
- ↑ Bruce, A. et al., 2008. Molecular biology of the cell, 5th ed, New York: Garland science, pp.909.