Inositiol 1,4,5 triphosphate: Difference between revisions
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Inisitol 1,4,5-triphosphate (IP<sub>3</sub>) is a water- soluble molecule, which is an intracellular mediator and a secondary messenger <ref>Unknown. (Undated). Second Messengers: IP3 and DAG. Available: http://courses.washington.edu/conj/gprotein/ip3.htm. Last accessed 28 Nov 2013.</ref>. It is responsible for increasing the concentration of Ca<sup>2+</sup>. | Inisitol 1,4,5-triphosphate (IP<sub>3</sub>) is a water- soluble molecule, which is an intracellular mediator and a [[Secondary_messenger|secondary messenger]] <ref>Unknown. (Undated). Second Messengers: IP3 and DAG. Available: http://courses.washington.edu/conj/gprotein/ip3.htm. Last accessed 28 Nov 2013.</ref>. It is responsible for increasing the concentration of Ca<sup>2+</sup>. | ||
IP<sub>3</sub> is produced when phospholipase C, a plasma bound enzyme, is activated by the alpha subunit of a trimeric G protein<ref>Unknown. (Undated). Second Messengers: IP3 and DAG. Available: http://courses.washington.edu/conj/gprotein/ip3.htm. Last accessed 28 Nov 2013.</ref> called Gq. The enzyme then cleaves a phosphorylated inositol phospholipid, called phosphatidylinositol 4,5-biphosphate (PIP<sub>2</sub>), producing IP<sub>3</sub> and diacylglycerol as the two products <ref>Alberts, B et al (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p909-p911</ref>. | IP<sub>3</sub> is produced when [[phospholipase C|phospholipase C]], a plasma bound enzyme, is activated by the alpha subunit of a [[Trimeric_G-protein|trimeric G protein]]<ref>Unknown. (Undated). Second Messengers: IP3 and DAG. Available: http://courses.washington.edu/conj/gprotein/ip3.htm. Last accessed 28 Nov 2013.</ref> called Gq. The enzyme then cleaves a phosphorylated inositol phospholipid, called [[phosphatidylinositol 4,5-biphosphate|phosphatidylinositol 4,5-biphosphate]] (PIP<sub>2</sub>), producing IP<sub>3</sub> and [[diacylglycerol|diacylglycerol]] as the two products <ref>Alberts, B et al (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p909-p911</ref>. | ||
IP<sub>3</sub> diffuses through the cytosol and into the endoplasmic reticulum (ER), where it binds to IP<sub>3</sub>- gated Ca<sup>2+</sup>- release channels (ligand-gated ion channels<ref>Unknown. (Undated). Second Messengers: IP3 and DAG. Available: http://courses.washington.edu/conj/gprotein/ip3.htm. Last accessed 28 Nov 2013.</ref>) , which are also called IP<sub>3</sub> receptors <ref>Alberts, B et al (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p909-p911</ref>. This causes stored Ca<sup>2+ </sup>to be released, increasing its concentration. The rise in Ca<sup>2+</sup> concentration, along with the second product diacylglycerol, helps to activate protein kinase C, which phosphorylates certain target proteins<ref>Alberts, B et al (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p909-p911.</ref>. | IP<sub>3</sub> diffuses through the cytosol and into the [[endoplasmic reticulum|endoplasmic reticulum]] (ER), where it binds to IP<sub>3</sub>- gated Ca<sup>2+</sup>- release channels ([[ligand-gated ion channels|ligand-gated ion channels]]<ref>Unknown. (Undated). Second Messengers: IP3 and DAG. Available: http://courses.washington.edu/conj/gprotein/ip3.htm. Last accessed 28 Nov 2013.</ref>) , which are also called IP<sub>3</sub> receptors <ref>Alberts, B et al (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p909-p911</ref>. This causes stored Ca<sup>2+ </sup>to be released, increasing its concentration. The rise in Ca<sup>2+</sup> concentration, along with the second product diacylglycerol, helps to activate [[protein kinase C|protein kinase C]], which phosphorylates certain target proteins<ref>Alberts, B et al (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p909-p911.</ref>. | ||
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Latest revision as of 03:39, 29 November 2013
Inisitol 1,4,5-triphosphate (IP3) is a water- soluble molecule, which is an intracellular mediator and a secondary messenger [1]. It is responsible for increasing the concentration of Ca2+.
IP3 is produced when phospholipase C, a plasma bound enzyme, is activated by the alpha subunit of a trimeric G protein[2] called Gq. The enzyme then cleaves a phosphorylated inositol phospholipid, called phosphatidylinositol 4,5-biphosphate (PIP2), producing IP3 and diacylglycerol as the two products [3].
IP3 diffuses through the cytosol and into the endoplasmic reticulum (ER), where it binds to IP3- gated Ca2+- release channels (ligand-gated ion channels[4]) , which are also called IP3 receptors [5]. This causes stored Ca2+ to be released, increasing its concentration. The rise in Ca2+ concentration, along with the second product diacylglycerol, helps to activate protein kinase C, which phosphorylates certain target proteins[6].
References
- ↑ Unknown. (Undated). Second Messengers: IP3 and DAG. Available: http://courses.washington.edu/conj/gprotein/ip3.htm. Last accessed 28 Nov 2013.
- ↑ Unknown. (Undated). Second Messengers: IP3 and DAG. Available: http://courses.washington.edu/conj/gprotein/ip3.htm. Last accessed 28 Nov 2013.
- ↑ Alberts, B et al (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p909-p911
- ↑ Unknown. (Undated). Second Messengers: IP3 and DAG. Available: http://courses.washington.edu/conj/gprotein/ip3.htm. Last accessed 28 Nov 2013.
- ↑ Alberts, B et al (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p909-p911
- ↑ Alberts, B et al (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. p909-p911.