Abc transporter protein: Difference between revisions
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ABC transporters are a | ABC transporters are one of the largest families (a superfamily) of transport [[Proteins|proteins]], that transport a wide variety of molecules ranging from small [[Ions]] to large [[macromolecules]]<span style="line-height: 1.5em;">. ABC transporters are typically composed of 4 main domains, these consist of 2 catalytic </span>[[ATPase domain|ATPase domains]]<span style="line-height: 1.5em;"> (also known as ABC)</span><span style="line-height: 1.5em;"> and 2 </span>[[transmembrane domains]]<span style="line-height: 1.5em;">.<ref>http://www.ebi.ac.uk/interpro/entry/IPR010067</ref> W</span><span style="line-height: 1.5em;">hen </span>[[ATP|ATP]]<span style="line-height: 1.5em;"> binds to the ABC modules, </span><span style="line-height: 1.5em;">the two domains dimerize, and when ATP is hydrolyzed they dissociate. The conformational change in the ABC transporter results in a change in the membrane itself, revealing a substrate binding site. This is thought to be how ABC transporters move small molecules across membranes.</span><ref>Alberts, B et al., 2007. Molecular Biology of the Cell, 5th edition. Garland Science, pg. 663</ref> | ||
ABC transporters are found in all species of animals, from humans all the way down to simple single-celled microbes. | |||
=== References === | === References === | ||
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Revision as of 17:59, 21 October 2014
ABC transporters are one of the largest families (a superfamily) of transport proteins, that transport a wide variety of molecules ranging from small Ions to large macromolecules. ABC transporters are typically composed of 4 main domains, these consist of 2 catalytic ATPase domains (also known as ABC) and 2 transmembrane domains.[1] When ATP binds to the ABC modules, the two domains dimerize, and when ATP is hydrolyzed they dissociate. The conformational change in the ABC transporter results in a change in the membrane itself, revealing a substrate binding site. This is thought to be how ABC transporters move small molecules across membranes.[2]
ABC transporters are found in all species of animals, from humans all the way down to simple single-celled microbes.
References
- ↑ http://www.ebi.ac.uk/interpro/entry/IPR010067
- ↑ Alberts, B et al., 2007. Molecular Biology of the Cell, 5th edition. Garland Science, pg. 663