DNA ligase I: Difference between revisions
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DNA ligase is an enzyme involved in [[DNA replication,|DNA replication,]] as well as repairing [[DNA|DNA]]. It catalyses the [[ | DNA ligase is an enzyme involved in [[DNA replication,|DNA replication,]] as well as repairing [[DNA|DNA]]. It catalyses the [[Phosphodiester bond|phosphodiester]] between the [[3' hydroxyl group|3' hydroxyl group]] and the [[5' phosphate group|5' phosphate group]] of [[Nucleotides|nucleotides]] in the DNA backbone. In particular, DNA ligase 1 joins [[Okazaki fragments|Okazaki fragments]] formed on the lagging strand to form a complete [[DNA|DNA]] strand<ref>Page 272, Alberts et al, Molecular Biology of the Cell, 5th edition, 2008.</ref><ref>http://www.biochem.umd.edu/biochem/kahn/molmachines/replication/DNA%20Ligase.htm</ref>. | ||
=== References === | === References === | ||
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Latest revision as of 16:03, 9 November 2015
DNA ligase is an enzyme involved in DNA replication, as well as repairing DNA. It catalyses the phosphodiester between the 3' hydroxyl group and the 5' phosphate group of nucleotides in the DNA backbone. In particular, DNA ligase 1 joins Okazaki fragments formed on the lagging strand to form a complete DNA strand[1][2].
References
- ↑ Page 272, Alberts et al, Molecular Biology of the Cell, 5th edition, 2008.
- ↑ http://www.biochem.umd.edu/biochem/kahn/molmachines/replication/DNA%20Ligase.htm