Tata box: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
Cleaned up the refs, and added in some links. |
||
| Line 1: | Line 1: | ||
The TATA box is the 5' TATA 3' sequence which is found in the [[DNA|DNA]] strand of a [[Promoter|promoter]] and is found in the core elements. The TATA box is usually found near the -31--26 region of the promoter and its sequence is T - A -T - A - A/T - A - A/T - A/G. The TATA box is a common promoter sequence reconised by RNA Polymerase II. It is found in both [[Prokaryotes|prokaryotes]] and [[Eukaryotes|eukaryotes]] however in the two it's spacing from the transcriptional start site differs. A eukaryotic cell does not have to have a TATA box and can instead have a combination of different core promoter elements. In mammals ~60-70% of protein coding genes lack the obvious TATA sequence and it is therefore transcription can occur at other start sites, such as CpG islands<ref>http://dwb4.unl.edu/Chem/CHEM869N/CHEM869NLinks/www.bio.davidson.edu/Biology/Courses/Molbio/MolStudents/01frschnell/genbank.html</ref>.<br> | The TATA box is the 5' TATA 3' sequence which is found in the [[DNA|DNA]] strand of a [[Promoter|promoter]] and is found in the core elements. The TATA box is usually found near the -31--26 region of the promoter and its sequence is T - A -T - A - A/T - A - A/T - A/G. The TATA box is a common promoter sequence reconised by [[RNA Polymerase II|RNA Polymerase II]]. It is found in both [[Prokaryotes|prokaryotes]] and [[Eukaryotes|eukaryotes]] however in the two it's spacing from the [[transcriptional start site|transcriptional start site]] differs. A [[eukaryotic|eukaryotic]] cell does not have to have a TATA box and can instead have a combination of different [[core promoter elements|core promoter elements]]. In [[mammals|mammals]] ~60-70% of [[protein coding genes|protein coding genes]] lack the obvious TATA sequence and it is therefore transcription can occur at other start sites, such as [[CpG_island|CpG islands]]<ref>http://dwb4.unl.edu/Chem/CHEM869N/CHEM869NLinks/www.bio.davidson.edu/Biology/Courses/Molbio/MolStudents/01frschnell/genbank.html</ref><ref>https://www.ncbi.nlm.nih.gov/protein/EJG07979.1</ref>.<br> | ||
=== References === | === References === | ||
<references /> | |||
Revision as of 12:22, 20 October 2016
The TATA box is the 5' TATA 3' sequence which is found in the DNA strand of a promoter and is found in the core elements. The TATA box is usually found near the -31--26 region of the promoter and its sequence is T - A -T - A - A/T - A - A/T - A/G. The TATA box is a common promoter sequence reconised by RNA Polymerase II. It is found in both prokaryotes and eukaryotes however in the two it's spacing from the transcriptional start site differs. A eukaryotic cell does not have to have a TATA box and can instead have a combination of different core promoter elements. In mammals ~60-70% of protein coding genes lack the obvious TATA sequence and it is therefore transcription can occur at other start sites, such as CpG islands[1][2].