Α-Ketoglutarate dehydrogenase: Difference between revisions

From The School of Biomedical Sciences Wiki
Jump to navigation Jump to search
mNo edit summary
No edit summary
Line 1: Line 1:
Pronounced alpha-ketoglutarate dehydrogenase this is a complex formed from three kinds of enzymes found in the citric acid cycle (CAC).<br>It catalyses the oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA&nbsp;[1].  
Pronounced alpha-ketoglutarate dehydrogenase this is a complex formed from three kinds of [[Enzymes|enzymes]] found in the [[Citric acid cycle|citric acid cycle ]](CAC).<br>It catalyses the [[Oxidative decarboxylation|oxidative decarboxylation]] of alpha-ketoglutarate to [[Succinyl CoA|succinyl CoA]] <sup></sup><ref>Berg J, Tymoczko J, Gatto G, Stryer L. Biochemistry. 8th ed. New York: W.H. Freeman; 2015. p. 505</ref><sup></sup>.  


The reaction is as follows:<br>alpha-Ketoglutarate + NAD + CoA -----► Succinyl CoA + CO2 + NADH&nbsp;<sup></sup>  
The reaction is as follows:<br>alpha-Ketoglutarate + NAD + CoA -----► Succinyl CoA + CO<sub>2</sub> + NADH&nbsp;<sup></sup>  


1. &nbsp; &nbsp; &nbsp; Berg J, Tymoczko J, Gatto G, Stryer L. Biochemistry. 8th ed. New York: W.H. Freeman; 2015. p. 505<br>
=== References  ===


<br>  
<references /><br>


To be completed
&nbsp;

Revision as of 12:35, 1 December 2016

Pronounced alpha-ketoglutarate dehydrogenase this is a complex formed from three kinds of enzymes found in the citric acid cycle (CAC).
It catalyses the oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA [1].

The reaction is as follows:
alpha-Ketoglutarate + NAD + CoA -----► Succinyl CoA + CO2 + NADH 

References

  1. Berg J, Tymoczko J, Gatto G, Stryer L. Biochemistry. 8th ed. New York: W.H. Freeman; 2015. p. 505