Oxidative decarboxylation

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Oxidative decarboxylation is a process in which carbon dioxide is produced through the removal of a carbon group as a result of oxidation reactions.[1] There are vital in many biological processes such as the citric acid cycle

In the citric acid cycle it is used three times to generate CO2 whilst also reducing NAD+ to NADH. Firstly, pyruvate is converted by a pyruvate dehydrogenase complex to Acetyl CoA.[2] Secondly, using the enzyme Isocitrate dehydrogenase to α-Ketoglutarate and finally α-Ketoglutarate dehydrogenase is used to convert α-Ketoglutarate to Succinyl CoA.[3][4]

References

  1. Voet, Donald; Voet, Judith; Pratt, Charlotte (2013). Fundamentals of Biochemistry (4 ed.). John Wiley and Sons.
  2. Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company. p477
  3. Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company.
  4. Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company. p485
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