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There are two types of cilia; motile and primary. Motile cilia grow in clusters e.g. the cells in the bronchial epithelium, primary cilia grow as a single cilium e.g. those on the embryonic node. Motile cilia are found on a limited range of different cell types whereas primary cilia are found on nearly every cell in the human body. Primary cilia's function is to recieve signals from other cells or fluids. | There are two types of cilia; motile and primary, and they tend to be around 10um in length and around 0.2um in diameter<ref>The Histology Guide - The University of Leeds. Epithelia: Specialisations; Available from: http://www.histology.leeds.ac.uk/tissue_types/epithelia/epi_specialisations.php</ref>. Motile cilia grow in clusters e.g. the cells in the bronchial epithelium, primary cilia grow as a single cilium e.g. those on the embryonic node. Motile cilia are found on a limited range of different cell types whereas primary cilia are found on nearly every cell in the human body. Primary cilia's function is to recieve signals from other cells or fluids. | ||
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Cilia (singular: Cilium) are cylindrical [[Organelles|organelles]]<ref>5) “Fundamental role of microvilli in the main functions of differentiated cells: Outline of an universal regulating and signalling system at the cell periphery” K. Lange, J Cell Physiol. 2011, 226, 896-927 Abstract. https://www.ncbi.nlm.nih.gov/pubmed/20607764</ref><ref>Lynn H. (2008) The Ciliated Protozoa Characterization, Classification, and Guide to the Literature, New York: Springer</ref>, built from [[Microtubules|microtubules]], in a “9 + 2” arrangement<ref>Lynn H. (2008) The Ciliated Protozoa Characterization, Classification, and Guide to the Literature, New York: Springer</ref>, and [[Dyneins|dyneins]] (see Figure 1). The majority of cilia in different [[Eukaryotes|eukaryotes]] have this characteristic arrangement<ref>Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, New York; Garland Science. 2015 (page 941-942)</ref>. They are [[Motile|motile]] structures whereby the rhythmic beating of cilia creates movement. Cilia are involved in [[Mucociliary clearance|mucociliary clearance]] in which [[Bacteria|bacteria]], [[Mucus|mucus]] and dust are swept up the [[Respiratory tract|respiratory tract]] into the [[Mouth|mouth]] and eliminated by swallowing. Moreover, ciliated cells move [[Oocytes|oocytes]] along the fallopian tubes, and [[Sperm|sperm]] from testes into the male reproductive tract<ref>Martini FH, Nath JL, Bartholomew EF. Fundamentals of Anatomy and Physiology. 9th Ed, San Francisco; Pearson Education Inc: 2012 (page 70-71)</ref>. Furthermore, by the beating of cilia, single cells are able to propel through fluid<ref>Alberts, Bruce et al. (2008). Molecular Biology of the Cell, 5th edition, New York: Garland Science. (Page 1031)</ref>. The movement of cilia is caused by axoneme, which can reach a length of 10-200 micrometers<ref>Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, New York; Garland Science 2015 (page 941-942)</ref>. Dynein is a cytoskeleton motor protein within cilia which enables them to have movement. This occurs by the conversion of chemical energy in [[ATP|ATP]] to mechanical energy.<ref>https://www.ncbi.nlm.nih.gov/pubmed/20607764</ref> | Cilia (singular: Cilium) are cylindrical [[Organelles|organelles]]<ref>5) “Fundamental role of microvilli in the main functions of differentiated cells: Outline of an universal regulating and signalling system at the cell periphery” K. Lange, J Cell Physiol. 2011, 226, 896-927 Abstract. https://www.ncbi.nlm.nih.gov/pubmed/20607764</ref><ref>Lynn H. (2008) The Ciliated Protozoa Characterization, Classification, and Guide to the Literature, New York: Springer</ref>, built from [[Microtubules|microtubules]], in a “9 + 2” arrangement<ref>Lynn H. (2008) The Ciliated Protozoa Characterization, Classification, and Guide to the Literature, New York: Springer</ref>, and [[Dyneins|dyneins]] (see Figure 1). The majority of cilia in different [[Eukaryotes|eukaryotes]] have this characteristic arrangement<ref>Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, New York; Garland Science. 2015 (page 941-942)</ref>. They are [[Motile|motile]] structures whereby the rhythmic beating of cilia creates movement. Cilia are involved in [[Mucociliary clearance|mucociliary clearance]] in which [[Bacteria|bacteria]], [[Mucus|mucus]] and dust are swept up the [[Respiratory tract|respiratory tract]] into the [[Mouth|mouth]] and eliminated by swallowing. Moreover, ciliated cells move [[Oocytes|oocytes]] along the fallopian tubes, and [[Sperm|sperm]] from testes into the male reproductive tract<ref>Martini FH, Nath JL, Bartholomew EF. Fundamentals of Anatomy and Physiology. 9th Ed, San Francisco; Pearson Education Inc: 2012 (page 70-71)</ref>. Furthermore, by the beating of cilia, single cells are able to propel through fluid<ref>Alberts, Bruce et al. (2008). Molecular Biology of the Cell, 5th edition, New York: Garland Science. (Page 1031)</ref>. The movement of cilia is caused by axoneme, which can reach a length of 10-200 micrometers<ref>Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, New York; Garland Science 2015 (page 941-942)</ref>. Dynein is a cytoskeleton motor protein within cilia which enables them to have movement. This occurs by the conversion of chemical energy in [[ATP|ATP]] to mechanical energy.<ref>https://www.ncbi.nlm.nih.gov/pubmed/20607764</ref> | ||
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== Primary Cilia == | == Primary Cilia == | ||
Revision as of 23:52, 4 December 2016
There are two types of cilia; motile and primary, and they tend to be around 10um in length and around 0.2um in diameter[1]. Motile cilia grow in clusters e.g. the cells in the bronchial epithelium, primary cilia grow as a single cilium e.g. those on the embryonic node. Motile cilia are found on a limited range of different cell types whereas primary cilia are found on nearly every cell in the human body. Primary cilia's function is to recieve signals from other cells or fluids.
Motile Cilia
Cilia (singular: Cilium) are cylindrical organelles[2][3], built from microtubules, in a “9 + 2” arrangement[4], and dyneins (see Figure 1). The majority of cilia in different eukaryotes have this characteristic arrangement[5]. They are motile structures whereby the rhythmic beating of cilia creates movement. Cilia are involved in mucociliary clearance in which bacteria, mucus and dust are swept up the respiratory tract into the mouth and eliminated by swallowing. Moreover, ciliated cells move oocytes along the fallopian tubes, and sperm from testes into the male reproductive tract[6]. Furthermore, by the beating of cilia, single cells are able to propel through fluid[7]. The movement of cilia is caused by axoneme, which can reach a length of 10-200 micrometers[8]. Dynein is a cytoskeleton motor protein within cilia which enables them to have movement. This occurs by the conversion of chemical energy in ATP to mechanical energy.[9]
Primary Cilia
Cilia can also be immotile (primary cilia) and have a “9+0” arrangement where they have 9 peripheral doublet microtubules and 0 single microtubules in the centre[10][11].
References
- ↑ The Histology Guide - The University of Leeds. Epithelia: Specialisations; Available from: http://www.histology.leeds.ac.uk/tissue_types/epithelia/epi_specialisations.php
- ↑ 5) “Fundamental role of microvilli in the main functions of differentiated cells: Outline of an universal regulating and signalling system at the cell periphery” K. Lange, J Cell Physiol. 2011, 226, 896-927 Abstract. https://www.ncbi.nlm.nih.gov/pubmed/20607764
- ↑ Lynn H. (2008) The Ciliated Protozoa Characterization, Classification, and Guide to the Literature, New York: Springer
- ↑ Lynn H. (2008) The Ciliated Protozoa Characterization, Classification, and Guide to the Literature, New York: Springer
- ↑ Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, New York; Garland Science. 2015 (page 941-942)
- ↑ Martini FH, Nath JL, Bartholomew EF. Fundamentals of Anatomy and Physiology. 9th Ed, San Francisco; Pearson Education Inc: 2012 (page 70-71)
- ↑ Alberts, Bruce et al. (2008). Molecular Biology of the Cell, 5th edition, New York: Garland Science. (Page 1031)
- ↑ Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, New York; Garland Science 2015 (page 941-942)
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/20607764
- ↑ Satir P, Pedersen LB, Christensen ST. The primary cilium at a glance. Journal of Cell Science 2010; 123(499-503): 1. http://jcs.biologists.org/content/123/4/499 (accessed 14 November 2016).
- ↑ 5) “Fundamental role of microvilli in the main functions of differentiated cells: Outline of an universal regulating and signalling system at the cell periphery” K. Lange, J Cell Physiol. 2011, 226, 896-927 Abstract. https://www.ncbi.nlm.nih.gov/pubmed/20607764