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The CpG sites or CG sites are regions of [[DNA|DNA]] where a [[cytosine|cytosine]] [[nucleotide|nucleotide]] is followed by a [[guanine|guanine]] nucleotide in the linear [[Sequence|sequence]] of bases along its 5' → 3' direction. CpG is shorthand for 5'—C—phosphate—G—3' , that is, cytosine and guanine separated by only one [[phosphate group|phosphate]]; phosphate links any two [[nucleosides|nucleosides]] together in [[DNA|DNA]] <ref>Jabbari K, Bernardi G (May 2004). "Cytosine methylation and CpG, TpG (CpA) and TpA frequencies". Gene. 333: 143–9. PMID 15177689. doi:10.1016/j.gene.2004.02.043.</ref>. The CpG notation is used to distinguish this single-stranded linear sequence from the CG base-pairing of cytosine and guanine for double-stranded sequences. | |||
The CpG sites or CG sites are regions of [[DNA|DNA]] where a [[ cytosine nucleotide | | |||
=== Reference === | === Reference === | ||
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Revision as of 19:06, 22 October 2017
The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction. CpG is shorthand for 5'—C—phosphate—G—3' , that is, cytosine and guanine separated by only one phosphate; phosphate links any two nucleosides together in DNA [1]. The CpG notation is used to distinguish this single-stranded linear sequence from the CG base-pairing of cytosine and guanine for double-stranded sequences.
Reference
- ↑ Jabbari K, Bernardi G (May 2004). "Cytosine methylation and CpG, TpG (CpA) and TpA frequencies". Gene. 333: 143–9. PMID 15177689. doi:10.1016/j.gene.2004.02.043.