Ran GTPase: Difference between revisions
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Ran is a monomeric [[GTPase|GTPase]] present in all [[cells|cells]], it is involved in nuclear transport through [[Nuclear pores|NPC's]]. Ran can exist in two conformations, it can be bound to [[GTP|GTP]] or [[GDP|GDP]]. [[Ran-GTP|Ran-GTP]] is mainly found in the nucleus, whereas Ran-GDP is more concentrated in the cytosol<ref>Jingyan Fu, Qing Jiang, Chuanmao Zhang.(2010) Coordination of Cell Cycle Events by Ran GTPase. Nature Education 3(9):32</ref>. In the nucleus, Ran-GTP binding to import receptors bound to cargo on the nuclear side stimulates the release of cargo into the [[nucleus|nucleus]]. After release, the import receptor bound to Ran-GTP is transported through the NPC to the cytoplasmic side, a regulatory protein [[Ran-GAP|Ran-GAP]], stimulates hydrolysis of Ran-GTP to Ran-GDP in the cytoplasm<ref>Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter. Molecular Biology of the Cell. 2008 Garland Science, New York. page 654</ref>. | |||
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Revision as of 21:04, 4 December 2017
Ran is a monomeric GTPase present in all cells, it is involved in nuclear transport through NPC's. Ran can exist in two conformations, it can be bound to GTP or GDP. Ran-GTP is mainly found in the nucleus, whereas Ran-GDP is more concentrated in the cytosol[1]. In the nucleus, Ran-GTP binding to import receptors bound to cargo on the nuclear side stimulates the release of cargo into the nucleus. After release, the import receptor bound to Ran-GTP is transported through the NPC to the cytoplasmic side, a regulatory protein Ran-GAP, stimulates hydrolysis of Ran-GTP to Ran-GDP in the cytoplasm[2].