Single-strand binding protein: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
Cleared up reference formatting |
||
| Line 1: | Line 1: | ||
A single-strand binding protein is able to bind to single stranded [[DNA|DNA]] during the process of DNA [[Semi-conservative replication|semi-conservative replication.]] It prevents the two DNA strands that are being used as templates reannealing to one another | A single-strand binding protein is able to bind to single stranded [[DNA|DNA]] during the process of DNA [[Semi-conservative replication|semi-conservative replication.]] It prevents the two DNA strands that are being used as templates reannealing to one another<ref>N. Campbell.(2005) Biology, 7th edition, USA: Pearson Education Inc</ref>. | ||
Single-strand binding (SSB) proteins work together with DNA helicase to unwind the helix and expose the template bases. SSB proteins assist helicase by stabilising the unwound, single-strand conformation. They also prevent short hairpin helices from forming by straightening out single-stranded DNA on the lagging strand | Single-strand binding (SSB) proteins work together with DNA helicase to unwind the helix and expose the template bases. SSB proteins assist helicase by stabilising the unwound, single-strand conformation. They also prevent short hairpin helices from forming by straightening out single-stranded DNA on the lagging strand<ref>Alberts, B. (2008). Molecular biology of the cell. New York: Garland Science. Pg 273.</ref>. SSB binds ssDNA tightly since it has a greater affinity for ssDNA than dsDNA. | ||
=== References === | === References === | ||
<references /><br> | <references /><br> | ||
Latest revision as of 10:53, 19 November 2018
A single-strand binding protein is able to bind to single stranded DNA during the process of DNA semi-conservative replication. It prevents the two DNA strands that are being used as templates reannealing to one another[1].
Single-strand binding (SSB) proteins work together with DNA helicase to unwind the helix and expose the template bases. SSB proteins assist helicase by stabilising the unwound, single-strand conformation. They also prevent short hairpin helices from forming by straightening out single-stranded DNA on the lagging strand[2]. SSB binds ssDNA tightly since it has a greater affinity for ssDNA than dsDNA.