CpG island: Difference between revisions
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[[CpG_island|CpG island]] is a region of [[DNA|DNA]] with higher than usual CG sequence content and mostly found in [[Promoter|promoter]] regions <ref>http://www.everythingbio.com/glos/definition.php?word=CpG+island</ref>. Usually unmethylated, CpG islands are important in [[Epigenetics|epigenetic control]] of [[Gene expression|gene expression]]. [[Methylation|Methylation]] of these regions can cause [[Cancer|cancer]] and other disease states <ref>Bock C, Paulsen M, Tierling S, Mikeska T, Lengauer T, et al. (2006) CpG Island Methylation in Human Lymphocytes Is Highly Correlated with DNA Sequence, Repeats, and Predicted DNA Structure. PLoS Genet 2(3): e26. doi:10.1371/journal.pgen.0020026</ref>. | [[CpG_island|CpG island]] is a region of [[DNA|DNA]] with higher than usual CG sequence content and mostly found in [[Promoter|promoter]] regions <ref>http://www.everythingbio.com/glos/definition.php?word=CpG+island</ref>. Usually unmethylated, CpG islands are important in [[Epigenetics|epigenetic control]] of [[Gene expression|gene expression]]. [[Methylation|Methylation]] of these regions can cause [[Cancer|cancer]] and other disease states <ref>Bock C, Paulsen M, Tierling S, Mikeska T, Lengauer T, et al. (2006) CpG Island Methylation in Human Lymphocytes Is Highly Correlated with DNA Sequence, Repeats, and Predicted DNA Structure. PLoS Genet 2(3): e26. doi:10.1371/journal.pgen.0020026</ref>.[[Restriction_enzyme|Restriction endonucleases]] (e.g., [[HpaII|''Hpa''II]]) that have CG in their recognition sequences can be used for CpG island identification. <ref>Harvey Lodish, Arnold Berk, S Lawrence Zipursky, Paul Matsudaira, David Baltimore, and James Darnell (2000). Molecular Cell Biology. 4th ed. New York: W.H.Freeman. p.366.</ref><br> | ||
== References == | == References == | ||
<references /> | <references /> | ||
Revision as of 19:33, 24 November 2011
CpG island is a region of DNA with higher than usual CG sequence content and mostly found in promoter regions [1]. Usually unmethylated, CpG islands are important in epigenetic control of gene expression. Methylation of these regions can cause cancer and other disease states [2].Restriction endonucleases (e.g., HpaII) that have CG in their recognition sequences can be used for CpG island identification. [3]
References
- ↑ http://www.everythingbio.com/glos/definition.php?word=CpG+island
- ↑ Bock C, Paulsen M, Tierling S, Mikeska T, Lengauer T, et al. (2006) CpG Island Methylation in Human Lymphocytes Is Highly Correlated with DNA Sequence, Repeats, and Predicted DNA Structure. PLoS Genet 2(3): e26. doi:10.1371/journal.pgen.0020026
- ↑ Harvey Lodish, Arnold Berk, S Lawrence Zipursky, Paul Matsudaira, David Baltimore, and James Darnell (2000). Molecular Cell Biology. 4th ed. New York: W.H.Freeman. p.366.