Uridine Diphosphate Glucose (UDP-glucose): Difference between revisions
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UDP-glucose is the activated form of glucose used in [[Glycogen synthesis|Glycogen synthesis]] as a glucose donor. The reaction of [[glucose 1-phosphate|glucose 1-phosphate]] and uridine triphosphate (UTP), catalysed by UDP-glucose pyrophosphorylase, forms UDP-glucose by the removal of two phorphoryl groups from the UTP <ref>Berg J, Tymoczko J and Stryr L (2011) Biochemistry, 7th edition, New York, W.H. Freeman</ref> . Glucose 1-phosphate + UTP + H<sub>2</sub>0 --------> UDP-glucose + 2P<sub>i </sub><br> | |||
[[Glycogen synthase|Glycogen synthase]] catalyses the formation of glycogen by adding the activated glucosyl unit from the UDP-glucose to the hydroxyl group on the carbon-4 atom of the glycogen molecule. | [[Glycogen synthase|Glycogen synthase]] catalyses the formation of glycogen by adding the activated [[glucosyl|glucosyl]] unit from the UDP-glucose to the [[hydroxyl|hydroxyl]] group on the carbon-4 atom of the [[glycogen|glycogen]] molecule. | ||
Glycogen synthesis reaction: Glycogen<sub>n</sub> + UDP-glucose ----> glycogen<sub>n+1</sub> + UDP<ref>Berg J, Tymoczko J and Stryr L (2011) Biochemistry, 7th edition, New York, W.H. Freeman</ref> <sub></sub> | Glycogen synthesis reaction: Glycogen<sub>n</sub> + UDP-glucose ----> glycogen<sub>n+1</sub> + UDP<ref>Berg J, Tymoczko J and Stryr L (2011) Biochemistry, 7th edition, New York, W.H. Freeman</ref> <sub></sub> | ||
=== References === | |||
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Latest revision as of 06:13, 28 November 2012
UDP-glucose is the activated form of glucose used in Glycogen synthesis as a glucose donor. The reaction of glucose 1-phosphate and uridine triphosphate (UTP), catalysed by UDP-glucose pyrophosphorylase, forms UDP-glucose by the removal of two phorphoryl groups from the UTP [1] . Glucose 1-phosphate + UTP + H20 --------> UDP-glucose + 2Pi
Glycogen synthase catalyses the formation of glycogen by adding the activated glucosyl unit from the UDP-glucose to the hydroxyl group on the carbon-4 atom of the glycogen molecule.
Glycogen synthesis reaction: Glycogenn + UDP-glucose ----> glycogenn+1 + UDP[2]
References