Uridine Diphosphate Glucose (UDP-glucose)

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UDP-glucose is the activated form of glucose used in Glycogen synthesis as a glucose donor. The reaction of glucose 1-phosphate and uridine triphosphate (UTP), catalysed by UDP-glucose pyrophosphorylase, forms UDP-glucose by the removal of two phorphoryl groups from the UTP [1] . Glucose 1-phosphate + UTP + H20 --------> UDP-glucose + 2P

Glycogen synthase catalyses the formation of glycogen by adding the activated glucosyl unit from the UDP-glucose to the hydroxyl group on the carbon-4 atom of the glycogen molecule. 

Glycogen synthesis reaction: Glycogenn + UDP-glucose ----> glycogenn+1 + UDP[2] 

References

  1. Berg J, Tymoczko J and Stryr L (2011) Biochemistry, 7th edition, New York, W.H. Freeman
  2. Berg J, Tymoczko J and Stryr L (2011) Biochemistry, 7th edition, New York, W.H. Freeman


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