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[[Immunoglobulin|Immunoglobulin]] E (IgE) is the protein in [[Antibody|antibodies]] associated with allergic responses and is produced when [[Allergen|allergens]] enter the body, consequently resulting in an allergic reaction <ref>Silverthorn, Dee Unglaub., Johnson, Bruce R., Ober, William C., Garrison, Claire W., Silverthorn, Andrew C.(2009)Human Physiology: An integrated approach, 5th edition, New York: Pearson International. p795</ref>. | [[Immunoglobulin|Immunoglobulin]] E (IgE) is the protein in [[Antibody|antibodies]] associated with allergic responses and is produced when [[Allergen|allergens]] enter the body, consequently resulting in an allergic reaction <ref>Silverthorn, Dee Unglaub., Johnson, Bruce R., Ober, William C., Garrison, Claire W., Silverthorn, Andrew C.(2009)Human Physiology: An integrated approach, 5th edition, New York: Pearson International. p795</ref>. | ||
IgE has a molecular weight of 200 | IgE has a molecular weight of 200 kDa, 5 domains and a ε chain. | ||
IgE is found in very low concentrations in serum and plays an important role in imflammation due to its high affinity to binding to FcRs (Fc receptors) on mast cells which casues mast cell degranulation. | IgE is found in very low concentrations in serum and plays an important role in imflammation due to its high affinity to binding to FcRs ([[Fc receptor|Fc receptors]]) on mast cells which casues [[mast cell degranulation|mast cell degranulation]]. | ||
=== References === | === References === | ||
<references /> | <references /> | ||
<br> | <br> | ||
Revision as of 10:57, 17 October 2013
Immunoglobulin E (IgE) is the protein in antibodies associated with allergic responses and is produced when allergens enter the body, consequently resulting in an allergic reaction [1].
IgE has a molecular weight of 200 kDa, 5 domains and a ε chain.
IgE is found in very low concentrations in serum and plays an important role in imflammation due to its high affinity to binding to FcRs (Fc receptors) on mast cells which casues mast cell degranulation.
References
- ↑ Silverthorn, Dee Unglaub., Johnson, Bruce R., Ober, William C., Garrison, Claire W., Silverthorn, Andrew C.(2009)Human Physiology: An integrated approach, 5th edition, New York: Pearson International. p795