Histamine
Histamine is a small molecule secreted by mast cells. When specific ligands bind to receptors on the mast cell surface, the mast cell is triggered and releases histamine. The released histamine enters nearby cells and causes inflammation.[1] Histamine causes the symptoms associated with allergic reactions such as sneezing and itching [2].
G-protein-coupled receptors respond to histamine. All of the G-protein coupled receptors which respond to histamine are involved with producing the inflammatory response[3].
References
- ↑ http://www.nhs.uk/Conditions/Antihistamines/Pages/How-does-it-work.aspx
- ↑ Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. (2008), Molecular Biology of the Cell, 5th edition, New York: Garland Science.
- ↑ H.P. Rang, M.M. Dale, J.M. Ritter, R.J. Flower, G.Henderson (2011)fckLRRang and Dale's pharmacology, 7th edition, page 211.