Haemolytic anaemia

From The School of Biomedical Sciences Wiki
Revision as of 15:02, 28 October 2017 by 150609575 (talk | contribs)
Jump to navigation Jump to search

 Haemolytic anaemia is a condition where haemolytic levels exceed erythrocyte production in the bone marrow, thereby resulting in anaemiaCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title.

Causes

There are intrinsic and extrinsic causes that may result in haemolytic anaemia:

Intrinsic:

  1. Defects in erythrocyte membranes[1]
  2. Defects in haemoglobin[2]
  3. Defects in erythrocyte metabolic pathways[3]


Extrinsic:

  1. Immune-mediated causes such as autoimmune haemolytic anaemia[4]
  2. Lead poisoning[5]
  3. Runners' macrocytosis (enlargement of red blood cells with near-constant hemoglobin concentration)[6]


References

  1. ↑ Gallagher PG. Abnormalities of the erythrocyte membrane. Pediatric Clinics of North America. 2013 Dec;60(6):1349.
  2. ↑ Forget BG, Bunn HF. Classification of the disorders of hemoglobin. Cold Spring Harbor perspectives in medicine. 2013 Feb 1;3(2):a011684.
  3. ↑ Jacobasch G, Rapoport SM. Hemolytic anemias due to erythrocyte enzyme deficiencies. Molecular aspects of medicine. 1996 Apr 1;17(2):143-70.
  4. ↑ Gehrs BC, Friedberg RC. Autoimmune hemolytic anemia. American journal of hematology. 2002 Apr 1;69(4):258-71.
  5. ↑ Valentine WN, Paglia DE, Fink K, Madokoro G. Lead poisoning: association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidines. Journal of Clinical Investigation. 1976 Oct;58(4):926.
  6. ↑ Eichner ER. Runner's macrocytosis: a clue to footstrike hemolysis. Runner's anemia as a benefit versus runner's hemolysis as a detriment. The American journal of medicine. 1985 Feb 1;78(2):321-5.







Retrieved from "https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Haemolytic_anaemia&oldid=18335"