Intragenic suppression

Intragenic suppression is what is used to reverse frameshift mutation. There are different types of intragenic suppression. The first type happens if there is an addition of a nucleotide to the mRNA, a deletion of a second nucleotide pair near the area where the addition occurred would nullify the effect. The reverse would be the case if there is a deletion of a nucleotide.

When a mutation like base substitution causes a change in the function of a protein, the second type of suppression helps to reverse this type of mutation. It does this by causing a mutation in another amino acid close to the area where the base substitution occured in the same protein.

REFERENCES

Daniel L. Hartl and Maryellen Ruvolo, (2012), Genetics: analysis of genes and genomes, 8th Edition: Page 555, Burlington, Jones & Bartlett Learning