Intragenic suppression

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Intragenic suppression is what is used to reverse frameshift mutation (e.g occurs in E. coli). There are different types of intragenic suppression. The first type happens if there is an addition of a nucleotide to the mRNA, a deletion of a second nucleotide pair near the area where the addition occurred would nullify the effect. The reverse would be the case if there is a deletion of a nucleotide.

When a mutation like base substitution causes a change in the function of a protein, the second type of suppression helps to reverse this type of mutation. It does this by causing a mutation in another amino acid close to the area where the base substitution occured in the same protein[1].


  1. Daniel L. Hartl and Maryellen Ruvolo, (2012), Genetics: analysis of genes and genomes, 8th Edition: Page 555, Burlington, Jones and Bartlett Learning
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